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Paediatric Laboratory Medicine

Trypsin, Blood

Clinical Significance

The clinical relevance of a serum TLI assay lies in the fact that being synthesized only by the pancreatic acinar cells, it is considered a specific indicator of pancreatic damage, unlike enzymes alpha-amylase and lipase usually employed in pancreatic diagnosis. This remark is supported bt the fact that totally pancreatectomized patients present zro TLI levels, but alpha-amylase values are within the normal range. In acute pancreatitis, TLI levels reach a maximum value of five to ten times higher than the upper normal limit and remain elevated for four to five days after the onset of abdominal pain. No overlap of these elevated levels with normal levels was ever observed, provided that patirnts affected by severe chronic renal failure (decreased TLI excretion) are not considered. Therefore, when interpreting high levels, the renal status of the patients should be evaluated. Up to now no serum test has been available to diagnose chronic pancreatitis. As pancreatic acini atrophy occurs in this disease, about 50% of patients show a trypsin level below the lower normal limit

Test Name

Trypsin, Blood

Alternate Name/ Synonym

Trysinogen

Test Code

TRYPS

Division

Biochemistry - Biochemistry

Method

RIA

Turn Around Time

Monthly

Specimen Type

Serum / EDTA plasma

Minimum Specimen Requirements

400 uL

Storage/Transportation

Frozen

Approval is not required

CPT Codes

83519

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Reference Range

10 - 57 ng/mL