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Paediatric Laboratory Medicine

Folate, Serum and RBC

Clinical Significance

Folates are a class of vitamin compounds related to pteroylglutamic acid (PGA), which serve as cofactors
in the enzymatic transfer of single carbon units in a variety of metabolic pathways Folates are necessary for nucleic acid and mitochondrial protein synthesis, amino acid metabolism, and other cellular processes that involve single carbon transfers Because deficiencies of both vitamin B12 and folate can lead to megaloblastic (macrocytic) anemia, appropriate treatment requires differential diagnosis of the deficiency; thus, both vitamin B12 and folate values are needed.folate values reflect the second stage of negative folate balance, and more closely correlate with tissue levels and megaloblastic anemia.

Test Name

Folate, Serum and RBC

Test Code



Biochemistry - Biochemistry


Abbott Ci4100

External Proficiency Testing


Specimen Type

Serum, Lithium Heparin plasma, Protect from light, K2, K3 EDTA for RBC Folate

Minimum Specimen Requirements

150 uL

Approval is not required

CPT Codes

82746 (Serum), 82747 (RBC)

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Phone: 416-813-7200
Phone: 1-855-381-3212

Reference Range

6.0-39.0 nmol/L

RBC Folate:
270 - 1176 nmol/L