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Paediatric Laboratory Medicine

LH, Blood

Clinical Significance

LH is a dimeric glycoprotein hormone secreted by the anterior pituitary in response to hypothalamic gonadotrophin releasing hormone. The α-subunit is common to other glycoprotein hormones, while the β-subunit, which confers biological activity, has some homology with that of human chorionic gonadotrophin. During the menstrual cycle, follicle stimulating hormone (FSH) stimulates growth of the ovarian follicle which, when mature, ovulates in response to a surge of LH and, to a lesser extent, of FSH. Ovarian steroids are the primary negative feedback control for LH secretion. At menopause, reduced ovarian negative feedback results in elevated LH concentrations. LH concentrations also tend to be elevated in women of pre‑menopausal age who experience ovarian failure, or whose ovaries failed to mature during puberty.

Test Name

LH, Blood

Test Code



Biochemistry - Biochemistry


Abbott Ci4100

External Proficiency Testing


Turn Around Time

Monday to Friday

Specimen Type

Serum, K EDTA plasma

Minimum Specimen Requirements

150 uL



Approval is not required

CPT Codes


Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Phone: 416-813-7200
Phone: 1-855-381-3212

Reference Range

<3m : 0.2-3.8 IU/L (Male)
<3m : <2.4 IU/L (Female)
3m-11m : <2.9 IU/L (Male)
3m-11m : <1.2 IU/L (Female)
1-9y : <0.3 IU/L (Male & Female)
10-12y : <4.3 IU/L (Male & Female)
13-14y : <4.1 IU/L (Male)
13-14y : 0.4-6.5 IU/L (Female)
15-16y : 0.8-4.8 IU/L (Male)
15-16y : <13.1 IU/L (Female)
17-18y : 0.9-7.1 IU/L (Male)
17-18y : <8.4 IU/L (Female)