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Paediatric Laboratory Medicine

B cell receptor gene rearrangement (IgH)

Clinical Significance

The presence of rearranged Immunoglobulin heavy chain receptor gene is useful in establishing clonality of B-cell and help in the diagnosis of B-cell lymphoproliferative disorders.

Test Name

B cell receptor gene rearrangement (IgH)

Gene Name

  • IgH gene

Division

Haematopathology- Molecular Haematology

Method

PCR (Polymerase chain reaction)

External Proficiency Testing

CAP

Turn Around Time

2-3 working days

Disease/Condition

B Cell ALL (Acute lymphocytic leukemia)

Specimen Type

Peripheral Blood, Bone Marrow Aspirate, Bodily Fluids

Minimum Specimen Requirements

2 mL

Storage/Transportation

Room Temperature (on ice if shipping takes more than 48 hrs).

Special Requirements

Peripheral Blood and Bone Marrow aspirate in EDTA or Sodium citrate

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212