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Paediatric Laboratory Medicine

Genetic screening for Factor II Prothrombin

Clinical Significance

The Factor II (Prothrombin) gene mutation G20210A is associated with increased prothrombin levels resulting in venous thrombosis and embolism.

Test Name

Genetic screening for Factor II Prothrombin

Gene Name

  • F II gene


Haematopathology- Molecular Haematology


RT PCR (Real-time polymerase chain reaction), with allele specific probe.

External Proficiency Testing


Turn Around Time

14 working days


Thromboembolic Diseases

Specimen Type

Peripheral Blood, Bone Marrow Aspirate

Minimum Specimen Requirements

2 mL


Room Temperature (on ice if shipping takes more than 48 hrs).

Special Requirements

Peripheral Blood and Bone Marrow aspirate in EDTA or Sodium citrate

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Phone: 416-813-7200
Phone: 1-855-381-3212