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The International Pediatric Oncology Guidelines in Supportive Care Network (iPOG Network)

The International Pediatric Oncology Guidelines in Supportive Care Network (iPOG Network) is an international group of organizations actively collaborating on clinical practice guidelines (CPGs) for supportive care of children with cancer or undergoing bone marrow transplant.

Working closely with trusted creators and users of supportive care CPGs, the iPOG Network aims to:

  • Develop an understanding towards creating better CPGs for the supportive care of children receiving cancer treatments and undergoing bone marrow transplants
  • Train and mentor students and clinicians in trustworthy, CPGs for children receiving cancer treatments and undergoing bone marrow transplants
  • Build capacity for trusted CPG creation to address the evolving needs of children receiving cancer treatments and undergoing bone marrow transplants
  • Systematically update existing CPGs as new evidence emerges
  • Facilitate the implementation of care consistent with the recommendations of CPGs
  • Evaluate patient and system outcomes resulting from consistent care following CPGs

About the network

Goal

Ensure every child receiving cancer treatment or undergoing bone marrow transplant receives the best available supportive care.

Vision

To enhance the quality of life of all children receiving cancer treatment and undergoing bone marrow transplant by accelerating the development and incorporation of supportive care into international standards of care.

The iPOG Network’s clinical practice guidelines are an ideal tool to achieve this vision.

Objectives

The iPOG Network aims to improve the quality of life for children with cancer or undergoing bone marrow transplant through ongoing development and refinement of high-quality clinical practice guidelines (CPGs) by:

  • Sharing best practices in CPG development
  • Avoiding inadvertent duplication by sharing guideline work plans and endorsement processes with the community
  • Communicating evidence gaps to the research community
  • Providing a forum for guideline dissemination and implementation discussions

Meetings

Representatives of member institutions meet by teleconference monthly and in person once a year; iPOG Network working groups meet by teleconference monthly.

Funding

Funding is generously provided by the Garron Family Cancer Centre at SickKids. iPOG Network activities are not directed or influenced by the funding agency.

Contribute to iPOG

Anyone developing and endorsing supportive care clinical practice guidelines in paediatric oncology are welcome to join the iPOG network.

Please contact Lee Dupuis at lee.dupuis@sickkids.ca to express your interest in the iPOG Network.

Identified research gaps

  • Emetogenicity classification of chemotherapy
    • Emetogenicity of chemotherapy and chemotherapy combinations where minimal direct paediatric evidence exists (e.g. dacarbazine, ifosfamide, intermediate dose methotrexate)
  • Prevention of acute chemotherapy-induced nausea and vomiting
    • Optimal dose of dexamethasone for use in children receiving highly emetogenic chemotherapy
    • Safe and effective alternatives to dexamethasone
    • Safe and effective alternatives to aprepitant
  • Prevention and treatment of anticipatory chemotherapy-induced nausea and vomiting
    • Optimal dose of lorazepam
  • Primary antifungal prophylaxis
  • Management of fever and neutropenia
  • Prevention of oral and oropharyngeal mucositis
  • Treatment of breakthrough chemotherapy-induced nasuea and vomiting
    • Efficacy of CINV prophylaxis escalation
  • Prevention of refractory chemotherapy-induced nausea and vomiting
    • Optimal palonosetron dose in children receiving multiple day chemotherapy

Clinical Practice Guideline resources

For more information related to CPGs, please visit the following organizations:

Contact us

Questions? Get in touch with iPOG or a Network member below:

Phone: 416-813-1500
Address: 555 University Ave, Toronto, ON M5G 1X8

Lee Dupuis
Organization: SickKids, POGO, COG
Email: Lee.dupuis@sickkids.ca

Wim Tissing
Organization: DCOG
Email: w.j.e.tissing@prinsesmaximacentrum.nl

Roland Ammann
Email: Roland.ammann@insel.ch

Andreas Groll
Email: grollan@ukmuenster.de

Catherine Lam
Organization: ASPHO
Email: Catherine.lam@stjude.org

Thomas Lehrbecher
Email: Thomas.lehrnbecher@kgu.de

Bob Phillips
Organization: CCLG
Email: Bob.phillips@doctors.org.uk

Carol Portwine
Organization: POGO
Email: portwc@mcmaster.ca

Paula Robinson
Organization: POGO, C17, COG
Email: probinson@pogo.ca

Marcel Romanick
Organization: C17
Email: Marcel.romanick@albertahealthservices.ca

Scott Howard
Organization: SIOP
Email: Scotth1375@gmail.com

Lillian Sung
Organization: POGO, C17, COG
Email: Lillian.sung@sickkids.ca

Marianne van de Wetering
Organization: DCOG
Email: m.d.vandewetering-4@prinsesmaximacentrum.nl

Sophie Wilne
Organization: CCLG
Email: Sophie.wilne@nuh.nhs.uk

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