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About Sickkids
About SickKids

L. Lee Dupuis, R.Ph., ACPR, M.Sc.Phm., FCSHP, PhD

The Hospital for Sick Children
Health Clinician Scientist
Pharmacy

Research Institute
Associate Scientist
Child Health Evaluative Sciences

University of Toronto
Associate Professor
Leslie Dan Faculty of Pharmacy; School of Graduate Studies


Phone: 416-813-7654 ext. 309355
Email: lee.dupuis@sickkids.ca
Alternate Contact: Nadica Dilev
Alternate Phone: 416-813-2162 ext. 302162
Alternate Email: nadica.dilev@sickkids.ca

For more information, visit:

International Pediatric Oncology Guidelines in Supportive Care Network (iPOG Network)

Brief Biography

  • Clinical practice in paediatric Haematology/Oncology and haematopoietic stem cell transplantation.
  • Co-chair of the Children’s Oncology Group Antiemetic Study Committee, Supportive Care Guideline Committee, and Pharmacy Research Committee; Co-chair of the Pediatric Oncology Group of Ontario Supportive Care Committee.
  • Member of the Children’s Oncology Group Pharmacy and Cancer Control & Supportive Care Committees; C17 Guidelines Committee and the Paediatric Expert Advisory Committee, Health Canada

Academic Background

2013 - PhD, Faculty of Medicine
University of Amsterdam
Supervisors: Drs. M. Offringa & H. Caron

1983 - M.Sc.Phm., Faculty of Pharmacy
University of Toronto
Supervisor: Dr. J. Thiessen

1982 - Hospital Pharmacy Residency, Sunnybrook Medical Centre
University of Toronto

1981 - B.Sc.Phm., Faculty of Pharmacy (with honours)
University of Toronto

Research Interests

Research focused on supportive care in cancer and haematopoietic stem cell transplant with emphasis on:

    • Optimization of the use of drugs in the prevention and management of chemotherapy-induced nausea and vomiting, infection, and the complications of haematopoietic stem cell transplant;  
    • Development of innovative methods for children with cancer to voice their own supportive care needs and priorities;
    • Development of innovative methods to facilitate the provision of evidence-based supportive care by health care providers and parents of children with cancer

External Funding

Preliminary Examination of the Impact of Cyclophosphamide Pharmacokinetic Variability on Outcomes in Paediatric Hematopoietic Stem Cell Transplantation. Garron Family Cancer Centre Small Grant Competition: $46,323: Nov 1 2012 – Oct 31, 2014; co-principal investigator.

Olanzapine for Prevention of Chemotherapy-induced Nausea and Vomiting in Children:  A Feasibility Study. POGO Seed Funding Grant: $14,943: 2013-2014; principal investigator.

Personalizing immunosuppression to improve age-related outcomes (POSITIVE). Canadian Institutes of Health Research: $1,500,000: 2013-18; co-investigator.

Development and validation of a pediatric cancer-specific symptom screening and assessment tool. Canadian Cancer Society Research Institute Impact Grant: $906,500: 2014-19; co-principal investigator.

Achievements

January 2011: 2010/2011 Patient Care Enhancement Award
Canadian Society of Hospital Pharmacists
A Reliable Method of Obtaining Blood Samples from Implantable Central Venous Catheters for Determination of Plasma Gentamicin Concentrations

January 2010: 2009/2010 Pharmacotherapy Best Practices Award
Canadian Society of Hospital Pharmacists
Once Daily Gentamicin Dosing in Febrile Neutropenic Children  

February 2008: 2007-08 Oncology Award
Canadian Society of Hospital Pharmacists
Efficacy and Safety of Caspofungin for the Empiric Management of Fever in Neutropenic Children

September 1995: Fellow
Canadian Society of Hospital Pharmacists

Publications

  1. Dupuis LL, Boodhan S, Sung L, Portwine C, Hain R, McCarthy P, Holdsworth M.  Guideline for the classification of the acute emetogenic potential of antineoplastic medication in pediatric cancer patients.  Pediatr Blood Cancer 2011; 57:191-8.
  2. Dupuis LL, Ethier MC, Tomlinson D, Hesser T, Sung L.  A systematic review of symptom assessment scales in children with cancer.  BMC Cancer 2012; 12: 430. PMID: 23009053
  3. Lehrnbecher T, Phillips R, Alexander S, Alvaro F, Carlesse F, Fisher B, Hakim H, Santolaya M, Castagnola E, Davis BL, Dupuis LL, Gibson F, Groll AH, Gaur A, Gupta A, Kebudi R, Petrilli A, Steinbach WJ, Villarroel M, Zaoutis T, Sung L. Guideline for the management of fever and neutropenia in children with cancer and/or undergoing hematopoietic stem cell transplantation. J Clin Oncol 2012; 30:4427-4438. PMID: 22987086
  4. Dupuis LL, Seto W, Teuffel O, Gibson P, Schultz K, Doyle J, Gassas A, Egeler RM, Sung L, Schechter T.  Prediction of area under the cyclosporine concentration vs time curve in children undergoing hematopoietic stem cell transplant.  Biol Blood Marrow Transplant 2013; 19: 418-23. PMID: 23128321
  5. Dupuis LL, Boodhan S, Holdsworth M, Robinson PD, Hain R, Portwine C, O’Shaughnessy E, Sung L.  Guideline for the prevention of acute nausea and vomiting due to antineoplastic medication in pediatric cancer patients. Pediatr Blood Cancer 2013; 60:1073-1082. PMID: 23512831
  6. Ansari M, Rao C, Uppugunduri S, Ferrari-Lacraz S, Bittencourt H, Gumy-Pause F, Chalandon Y, Tiercy J-M, Schechter T, Gassas A, Doyle JD, Dupuis L, Duval M, Krajinovic M, Villard J.  The clinical relevance of pre-formed anti-HLA and anti-MICA antibodies after cord blood transplantation in children. PLOS ONE 2013; 8:e72141.
  7. Mascarenhas A, Wong C, Mattiussi A, Alexander S, Lau E, Dupuis LL.  Methylnaltrexone for opioid-induced constipation in pediatric oncology patients. Pediatr Blood Cancer  2013; 60: 1667-70. PMID:
    23766091
  8. Tomlinson D, Dupuis LL, Gibson P, Johnston D, Portwine C, Baggott C, Zupanec S, Watson J, Spiegler B, Kuczynski S, Macartney G, Sung L. Initial development of the symptom screening in pediatric (SSPedi) tool. Supportive Care in Cancer 2014; 22:71-5.  see also Supportive Care in Cancer 2014; 22: 77-8. PMID: 23995756
  9. Science M, Robinson P, MacDonald T, Rassekh SR, Dupuis LL, Sung L. Guideline for primary antifungal prophylaxis for pediatric patients with cancer or hematopoietic stem cell transplant recipients.  Pediatric Blood & Cancer 2014; 61:393-400. PMID: 2442478
  10. Flank J and Dupuis LL.  Comparative effective research in antineoplastic-induced nausea and vomiting control in children. J Comp Eff Res 2014; 3: 185-96.
  11. Dupuis LL, Robinson PD, Boodhan S, Holdsworth M, Portwine C, Gibson P, Phillips, R, Maan, C, Stefin N, Sung L. Guideline for the prevention and treatment of anticipatory nausea and vomiting due to antineoplastic medication in pediatric cancer patients. Pediatric Blood & Cancer 2014; 61: 1506-12.
  12. O’Sullivan C, Dupuis LL, Gibson P, Johnston DL,  Baggott C, Portwine C, Spiegler B, Kuczynski S, Tomlinson D, de Mol Van Otterloo S, Tomlinson GA, Sung S.  Refinement of the Symptom Screening in Pediatrics Tool (SSPedi).  Brit J Cancer doi:10.1038/bjc.2014.445
  13. Flank J, Sung L, Dvorak C, Spettigue W, Dupuis LL.  The safety of olanzapine in young children: a systematic review and meta-analysis. Drug Safety 2014; DOI 10.1007/s40264-014-0219-y

Clinical Practice Guidelines

Barnard D, Portwine C, Sung L, Dupuis LL, Romanick M, Erdmann G, McDermid A, Choquette A, McCory M. Guideline for Platelet Transfusion Thresholds for Pediatric Hematology/ Oncology Patients, C17. June 2010. http://www.c17.ca/index.php?cID=68

Dupuis LL, Boodhan S, Sung L, Portwine C, Hain R, McCarthy P, Holdsworth M.  Guideline for the classification of the acute emetogenic potential of antineoplastic medication in pediatric cancer patients. Pediatric Oncology Group of Ontario. July 2010. http://www.pogo.ca/healthcare/practiceguidelines/pogoemetogenicitycla/

Science M, Dupuis LL, Robinson PD, MacDonald T, Rassekh R, Sung L.  Guideline for primary antifungal prophylaxis for pediatric haematology/oncology patients.  C17. June 2012. http://www.c17.ca/index.php?cID=86

Dupuis LL, Boodhan S, Holdsworth M, Robinson PD, Hain R, Portwine C, O’Shaughnessy E, Sung L.  Guideline for the prevention of acute nausea and vomiting due to antineoplastic medication in pediatric cancer patients. Pediatric Oncology Group of Ontario. August 2012. http://www.pogo.ca/healthcare/practiceguidelines/acuteainvguideline/

Dupuis LL, Robinson P, Holdsworth M, Portwine C, Gibson P, Phillips, R, Maan, C, Stefin N, Sung L. Guideline for the prevention and treatment of anticipatory nausea and vomiting due to antineoplastic medication in pediatric cancer patients. March 2014. http://www.pogo.ca/healthcare/practiceguidelines/anticipatorycinv/