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About Sickkids
About SickKids

Yigal Dror, MD, FRCP(C)

The Hospital for Sick Children
Staff Haematologist/Oncologist
Haematology/Oncology

Director
Marrow Failure and Myelodysplasia program

Research Institute
Senior Scientist
Genetics & Genome Biology

University of Toronto
Associate Professor
Paediatrics


Phone: 416-813-8886
Fax: 416-813-5327
Email: yigal.dror@sickkids.ca

For more information, visit:

Canadian Inherited Marrow Failure Study website

Brief Biography

Education:

  • Medical degree and Paediatrics specialty, The Hebrew University, Jerusalem, Israel
  • Paediatric Haematology/Oncology fellowship, Division of Haematology/Oncology, The Hospital for Sick Children, Toronto
  • Post-doctoral research fellowship in Hematopoiesis, Research Institute, The Hospital for Sick Children and the University of Toronto, Toronto

Current positions:

  • Director, Marrow Failure and Myelodysplasia Program (MFMP) - The Hospital for Sick Children, Toronto, ON (July 2002 – Present)
  • Associate Professor of Paediatrics, Department of Paediatrics, Faculty of Medicine, The University of Toronto, Toronto, ON (June 2004 - Present)
  • Member, Institute of Medical Science, Faculty of Medicine, The University of Toronto, Toronto, ON (March 2003 – Present)
  • Senior Scientist, Cell Biology, The Hospital for Sick Children, Toronto, ON (Scientist Track since 2000, Scientist since 2004 and Senior Scientist since 2011)

Clinical Care Activities 

  • Staff Haematologist, Haematology and Bone Marrow Transplant Program
  • Director, Marrow Failure and Myelodysplasia Program
  • The Canadian Inherited Marrow Failure Registry: deciphering the genetic and clinical characteristics of inherited bone marrow failure syndromes, including genotype-phenotype correlation.

Areas of Specialty 

Hematopoiesis, stem cells, apoptosis, SBDS, bone marrow failure, myelodysplastic syndromes, leukemia.

Research Interests

  • Bone marrow failure syndromes – genetic basis, molecular and cellular mechanisms and clinical outcome.
  • Myelodysplastic syndromes and leukemia - molecular and cellular mechanisms in bone marrow failure disorders.

Current Research Activities

  • Discovery of novel inherited bone marrow failure genes and syndromes.

External Funding

  • Seattle Children's Hospital Research Foundation - Butterfly Guild (2011-2012)
  • March of Dimes

Achievements

  • CIHR Clinical Investigator Award (2006)
  • The Hospital For Sick Children New Investigator Award (2006)
  • Recognition of the Division of Haematology/Oncology by the MDS as center of excellence in the treatment, research and education in myelodysplastic syndromes (2001)
  • The John H. Crookston Awards (1998)
  • Stanley Levin Scholarship Outstanding Pediatrician Award (1995)
  • The Hebrew University, Annual Deans Award for the academic years 1987-1988, 1986-1987, 1985-1986, 1984-1985, 1983-1984
  • The Anatomy Department Award 1984-1985

Awards for Trainees

  • Best Cell Biology Program Abstract prize. Research Institute Annual Summer Student Research Day. (For undergraduate student, Mr. David Liddle.) August 2011
  • Department of Paediatric Research Day, The Hospital for Sick Children. Best Basic Science Poster: (for a graduate student: Ms. Saswati Sen) 2009.  
  • Rising Stars in Research National Competition (for an undergraduate student: Mr. Manveen Puri). 2008
  • Ontario Graduate Scholarship Award: (For a graduate student: Saswati Sen). 2008
  • The Hospital for Sick Children Research Training Competition Award (for a graduate student, Saswati Sen). 2008
  • Department of Paediatric Research Day, Hospital for Sick Children. Best Basic Science Poster: (for a graduate student: Ms. Saswati Sen). 2009.  
  • Rising Stars in Research National Competition (for an undergraduate student: Mr. Manveen Puri). 2008.
  • Ontario Graduate Scholarship Award: (For a graduate student: Saswati Sen). 2008.
  • Canadian Society of Haematology Abstract Competition Award (for a Trainee Piya Rujkijyanont). 2007
  • American Society of Hematology Abstract Competition Award (for a Trainee Piya Rujkijanont). 2007
  • The Hospital for Sick Children Research Training Competition Award (for a post-doctoral fellow, Ken-ichiro Watanabe), 2004
  • American Society of Hematology Travel Award (for a Trainee: Arif Manji). 2003

Publications

Makaryan V, Kulik W, Allen C, Dror Y, Dale DC, Aprikyan AA. The Cellular and Molecular Mechanisms for Neutropenia in Barth Syndrome. Eur J Haematol. 2012 Mar;88(3):195-209. Epub 2011 Dec 4.

Sen S, Wang H, Nghiem CL, Zhou K, Yau J, Tailor C, Irwin M, Dror Y.  The ribosome-related protein, SBDS, is critical for normal erythropoiesis. Blood,2011:8;118(24):6407-17.

Dror Y, Donadieu J, Koglmeier J, Dodge J, Toiviainen-Salo S, Makitie O, Kerr E, Zeidler C, Shimamura A, Shah N, Cipolli M, Kuijpers T, Durie P, Rommens J, Siderius L, Liu JM, Shwachman-Diamond Syndrome: Consensus Guidelines. Ann N Y Acad Sci. 2011;1242(1):40-55

Tsangaris E, Klaassen R, Fernandez CV, Yanofsky R, Shereck E, Champagne J, Silva M, Lipton JH, Brossard J, Samson Y, Abish S, Steele M, Ali K, Dower N, Athale U, Jardine L, Hand JP, Stephen D, Odame I, Canning P, Allen C, Carcao M, Beyene J, Roifman CM, Dror Y. Genetic analysis of inherited bone marrow failure syndromes from one comprehensive and population-based cohort and identification of novel mutations. J Med Genet. 2011. 48(9):618-28

Hashmi SK, Allen C, Klaassen R, Fernandez CV, Yanofsky R, Shereck E, Champagne J, Silva M, Lipton JH, Brossard J, Samson Y, Abish S, Steele M, Ali K, Dower N, Athale U, Jardine L, Hand JP, Beyene J, Dror Y. Comparative analysis of Shwachman-Diamond Syndrome to other Inherited Marrow Failure Syndromes. Clinic Genet 2010

Rujkijyanont P, Adams S, Beyene J, Dror Y. Bone marrow cells from patients with Shwachman-Diamond Syndrome abnormally express genes involved in ribosome biogenesis and RNA processing. Brit J Haematol, 2009: 145(6): pp 806-15.

Watanabe K, Ambekar C, Wang W, Ciccolini A, Schimmer A, Dror Y. SBDS-deficiency results in specific hypersensitivity to Fas stimulation and accumulation of Fas at the plasma membrane. Apoptosis 2009: 14 (1): pp77-89. SRI

Ward AC, Gits J, Majeed F, Aprikyan AA, Lewis RS, O'Sullivan LA, Freedman M, Shigdar S, Touw IP, Dale DC, Dror Y. Functional interaction between mutations in the granulocyte colony-stimulating factor receptor in severe congenital neutropenia. Br J Haematol 2008:142:653-6

Dror Y. Shwachman-Diamond syndrome: implications for understanding the molecular basis of leukaemia. Expert Rev Mol Med. 2008: 10:e38.

Tsangaris E, Adams SL, Yoon G, Chitayat D, Lansdorp P, Dokal I, Dror Y. Ataxia and pancytopenia caused by a mutation in TINF2. Human Genetics 2008: 124 (5): pp507-13. SRI

Ward AC, Gits J, Majeed F, Aprikyan AA, Lewis RS, O'Sullivan LA, Freedman M, Shigdar S, Touw IP, Dale DC, Dror Y: Functional interaction between mutations in the granulocyte colony-stimulating factor receptor in severe congenital neutropenia. Br J Haematol. 2008

Teo JT, Klaassen R, Fernandez CV, Yanofsky R, Wu J, Champagne J, Silva M, Lipton JH, Brossard J, Samson Y, Abish S, Steele M, Ali K, Dower N, Uma Athale, Jardine L, Hand JP, Tsangaris E, Beyene B, Dror Y: Clinical and genetic analysis of unclassifiable inherited bone marrow failure syndromes. Pediatrics, In Press.

Rujkijyanont P, Watanabe KI, Ambekar C, Wang H, Schimmer AD, Beyene J, Dror Y: Sbds-deficient cells undergo accelerated apoptosis through the Fas-pathway and not through the Bax/Bcl2/BclXL pathway. Haematologica 2008:93;363-71.

Rosenberg PS, Alter BP, Link DC, Stein S, Rodger E, Bolyard AA, Aprikyan AA, Bonilla MA, Dror Y, Kannourakis G, Newburger PE, Boxer LA, Dale DC: Neutrophil Elastase Mutations and Risk of Leukemia in Severe Congenital Neutropenia. Brit J Haematol 2008:93;363-71.

Rujkijyanont P, Beyene J, Wei K, Kahn F, Dror Y: Leukemia-related gene expression in bone marrow cells from patients with the pre-leukemic disorder Shwachman-Diamond syndrome. Brit J Haematol 2007:137;537-44

Calado RT, Graf SA, Wilkerson KL, Kajigaya S, Ancliff PJ,Dror Y, Chanock SJ, Lansdorp PM, Young NS: Mutations in the SBDS gene in acquired aplastic anemia. Blood 2007:110:1141-6

Pongtanakul B, Das PK, Charpentier K, Dror Y. Outcome of children with aplastic anemia treated with immunosuppressive therapy. Pediatr Blood Cancer 2008 Jan; 140 (2): 210-3

Leung E, Rujkijyanont P, Beyene J, Wei K, Freedman J, Dror Y: Shwachman-Diamond Syndrome: an inherited model of aplastic anemia with increased angiogenesis. British Journal of Haematology. (British Journal of Haematology, Brit J Haematol 2006: 133:558-61

Cheretakis C, Leung R, Sun CX, Dror Y, Glogauer M: Timing of neutrophil tissue repopulation predicts restoration of innate immune protection in a murine bone marrow transplant model. Blood 2006:108:2821-6.

Steele JM, Sung L, Klaassen R, Fernandez CV, Yanofsky R, Wu J, Odame I, Silva M., Champagne J, Ali, K, Brossard J, Samson Y, Abish S, Le D, Jardine L, Hand JP, Lipton JH, Charpentier K, Stephens D, Freedman M, Dror Y: Disease Progression in Recently Diagnosed Patients with Inherited Marrow Failure Syndromes: A Canadian Inherited Marrow Failure Registry (CIMFR) Report. Pediatr Blood Cancer 2006:47:918-25.

Majeed F, Jadko S, Freedman M, Dror Y: Mutation analysis of SBDS in pediatric acute myeloblastic leukemia. Pediatr Blood Cancer 2005:45;920-4.

Dror Y, Gruenbaum E, Hitzler J, Narendran A, Ye C, Edwards V, Freedman M, Roifman C. Purine nucleoside phosphorylase deficiency associated with a dysplastic marrow morphology. Pediatr Res 2004:55:472-7.

Dror Y. The Role of Mitochondrial-Mediated Apoptosis in a Myelodysplastic Syndrome Secondary to Congenital Deletion of the Short Arm of Chromosome 4. Exp Hematol 2003;31:211-7.

Dror Y
, Durie P, Ginzberg H, Herman R, Banerjee A, Champagne M, Shannon K, Malkin D, Freedman MH. Clonal Evolution in Marrows of Patients with Shwachman-Diamond syndrome. Exp Hematol 2002;30:659-69.

Mandel K, Dror Y, Poon A, Freedman M: Practical classification of pediatric myelodysplasia (CCC system). J Pediatr Hematol/Oncol 2002;24:596-605.

Thornley I, Dror Y, Sung L, Wynn RF, Freedman MH: Abnormal telomere shortening in leukocytes of children with Shwachman-Diamond syndrome. Brit J Haematol 2002;117:189-92.

Dror Y
, Freedman MH. Marrow cells from Shwachman-Diamond syndrome (SDS) patients are characterized by abnormally increased apoptosis mediated through the Fas pathway. Blood 2001;97:3011-6.

Dror Y, Leaker M, Caruana G, Bernstein A, Freedman MH: Mastocytosis cells bearing a c-kit activation mutation are characterized by hypersensitivity to stem cell factor and increased programmed cell death. Brit J Haematol 2000;108:729-36.

Dror Y, Ward A, Tauw I, Freedman MH. Combined corticosteroid/granulocyte colony-stimulating factor (G-CSF) therapy in the treatment of severe congenital neutropenia unresponsive to G-CSF. Exp Hematol 2000;28:1381-9.

Dror Y, Freedman MH. Shwachman-Diamond syndrome is an inherited pre-leukemic bone marrow failure disorder with aberrant hematologic progenitors and faulty marrow microenvironment. Blood 1999;94:3048-54.

Dror Y, Squire J, Durie P, Freedman MH: Malignant myeloid transformation with isochromosome 7(q) in Shwachman-Diamond syndrome. Leukemia 1998; 12:1591-5.