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About Sickkids
About SickKids

Yigal Dror, MD, FRCP(C)

The Hospital for Sick Children
Staff Haematologist/Oncologist
Haematology/Oncology

Director
Marrow Failure and Myelodysplasia program

Research Institute
Senior Scientist
Genetics & Genome Biology

University of Toronto
Professor
Paediatrics

Member
Institute of Medical Sciences

Member
School of Graduate Studies


Phone: 416-813-5977
Fax: 416-813-5327
Email: yigal.dror@sickkids.ca
Alternate Contact: Samantha Singh
Alternate Phone: 416-813-7654 ext. 207758
Alternate Email: samantha.singh@sickkids.ca

For more information, visit:

Canadian Inherited Marrow Failure Study website

Marrow Failure and Myelodysplasia Program website

University of Toronto information

Brief Biography

Education:

  • Medical degree and Paediatrics specialty, The Hebrew University, Jerusalem, Israel
  • Paediatric Haematology/Oncology fellowship, Division of Haematology/Oncology, The Hospital for Sick Children, Toronto
  • Post-doctoral research fellowship in Hematopoiesis, Research Institute, The Hospital for Sick Children and the University of Toronto, Toronto

Current positions:

  • Director, Marrow Failure and Myelodysplasia Program (MFMP) - The Hospital for Sick Children, Toronto, ON (July 2002 – Present)
  • Professor of Paediatrics, Department of Paediatrics, Faculty of Medicine, The University of Toronto, Toronto, ON (June 2004 - Present)
  • Member, Institute of Medical Science, Faculty of Medicine, The University of Toronto, Toronto, ON (March 2003 – Present)
  • Senior Scientist, Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON (2011-Present)

Clinical Care Activities 

  • Staff Haematologist, Haematology and Bone Marrow Transplant Program
  • Director, Marrow Failure and Myelodysplasia Program

Areas of Specialty 

Bone marrow failure syndromes, Aplastic Anemia, Myelodysplastic syndromes, Leukemia, Leukemia-predisposition syndromes.

Research Interests

  • Hematopoiesis, Stem cells, Genetics/Genomics, Gene Discovery, Shwachman-Diamond syndrome, SBDS, DNAJC21

Current Research Activities

 Regulation of normal hematopoiesis
 Mechanisms of leukemia and MDS development
 Induced pluripotent stem cells
 Pathobiology of Shwachman-Diamond syndrome
 Gene Discovery

Selected Achievements

 Discovery of FAS pathway impairment and increased oxidative stress in primary cells and cellular models of Shwachman-Diamond syndrome that lead to reduced cell growth and blood cell formation
 Discovery of marrow stromal defects and increased angiogenesis in Shwachman-Diamond syndrome
 Discovering novel genes (e.g. PARN and DNAJC21) and pathways underlying bone marrow failure
 Demonstrating the diagnostic advantage and utility of a comprehensive next generation sequencing panel for all genes associated with bone marrow failure and of CNV screens
 Characterizing leukemic transformation and other clinical aspects of inherited bone marrow failure syndromes
 Lead the development of novel classification and diagnostic criteria for pediatric MDS
 Leads the following multicenter Canadian registries and network: Inherited Marrow Failure Registry, the Canadian Aplastic Anemia and Myelodysplastic Syndrome Study

Current Lab Members

 Hongbing Li (PhD), Research Technologist, Lab manager
 Bozana Zlateska (MSc Medicine, MD), Clinical Research Project Manager
 Mariana Benicio (PhD), Post-Doctoral Fellow
 Houtan Moshiri (PhD), Post-Doctoral Fellow
 Yeon Jung Lim (MD, PhD), Research fellow
 Santhosh Dhanraj (BSc), Graduate student
 Anna Matveev (BSc), Graduate student
 Alejandra Lagos (BSc), Graduate student

Lab Alumni

MFM Research and Clinical Fellowship: Stephanie Heidemann (MD),  Ibrahim Ghemlas, Nicolas Waespe, Supanun Lauhasurayotin (MD), Albert Catala (MD), Yeon Jung Lim (MD).
Post-Doctoral Research Fellows: Elaine Leung (MD), Piya Rujkiyanont (MD), Ken-ichiro Watanabe (MD), Bunchoo Pungtanakul (MD), Boonchai Boonyawat (MD), Chhaya Ambekar )PhD), Mariana Benicia (PhD), Houtan Moshiri (PhD)
Graduate Students
: Saswati Sen, Santhosh Dhanraj, Alice Luca, Stephanie Ng, Anna Matveev, Alejandra Lagos Monzon
Undergraduate Students (University Research project Course)
: Elena Tsangaris, Manveen Puri, Punit Saraon, Janice Yau, Chi Lan Nghein, David Choi, Richard Lee, Mathura Sabanayagam. Joseph Zhou
Summer Students: Arif Manji, Melanie Kalbfleisch, Michaela Gasner, Omri Arbiv. David Liddle, Peter Jaksa. Tom Chen, Amanda Ciccolini, Asad Naqvi, Kim Zhou, Mathura Sabanayagam, Saman Hashmi, Fahad Kahn,  Jennifer Lee, Janice Yau, Chi Lan Ngheim, Richard Heungki Lee, Preeti Sharma (Internship Placement), Emma Reble, Shirley Shuster, Tom Enbar. Rutvik Patel (Internship placement), Manju Wahala (Internship Placement), Katrina Sajewcyz, Megan Van Tassel (Internship placement), Brian Bursic, Kenssese Mossanda (Internship placement)
Clinical Fellows supervised on clinical research projects: Anjali Sharatkumar, Adam Gassas, Prabodh Das, Juliana Teo, Jillian Baker, MacGregor Steele, Paola Angelini, Vicky Breakey, Catherine Segbefia, Machiel Van Den Akker

External Funding

 Canadian Institute of Health Research
 C17 Research Network
 Aplastic Anemia and Myelodysplasia of Canada
 Fanconi Anemia Canada
 Diamond Blackfan Anemia Canada

Achievements

  • Visiting Professor, Children's Hospital of Eastern Ontario (2018)
  • Visiting Professor, University of Iowa (2018)
  • Visiting Professor, Texas Children's Hospital and Baylor College of Medicine Pediatric Hematology/Oncology, Houston, Texas (2016)
  • Dr. Bernard Lasi Award, Department of Paediatrics, The Hospital for Sick Children (2015)
  • Visiting Professor, Department of Pediatric Hematology/Oncology, CHU Ste-Justine, Montreal Quebec (2014)
  • Visiting Professor, Pediatric Grand Rounds, Kaplan Hospital, Rehovot, Israel (2013)
  • Research Institute Annual Summer Student Research Day Abstract Award (2012)
  • Department of Paediatric Research Day, Hospital for Sick Children, Best Abstract Award (2009, 2011)
  • Canadian Society of Haematology Abstract Competition Award (2007)
  • CIHR Clinical Investigator Award (2006)
  • Sickkids Foundation New Investigator Award (2006)
  • Sickkids Research Training Competition Award for Dr. Dror's trainees (2004, 2008)
  • MDS Center of Excellence (2001-Present)
  • ASH Abstract Awards (1999,2003,2007,2014)
  • The John H. Crookston Awards (1998)
  • Stanley Levin Scholarship Outstanding Pediatrician Award (1995)
  • The Anatomy Department Award 1985
  • The Hebrew University, Annual Deans Award (annually from 1984-1988)

Awards for Trainees

  • Mariana Benicio:  Abstract Award, Haemeatology Research Day 2018
  • Anna Matveev: Abstract Award, Haemeatology Research Day 2017
  • Omri Arbiv: Hematology Opportunities for the Next Generation of Research Scientists (HONORS) award, American Society of Haematology 2016
  • Nicolas Waespe: Garron Family Cancer Center Pitblado Clinical Discovery Grant Award 2016 
  • Nicolas Waespe: Abstract Award, Haemeatology Research Day 2016
  • Santhosh Djanraj: American Society of Hematology Abstract Award 2015
  • Santhosh Djanraj: University of Toronto School of Graduate Studies Trainee Abstract Award 2015
  • Ibrahim Ghemlas: Journal of Medical Genetics Editor's Choice paper 2015
  • Ibrahim Ghemlas: Abstract Award, Haematology Research Day 2014 
  • Ibrahim Ghemlas: American Society of Haematology Abstract Achievement Award 2014
  • Alice Luca: International SDS Congress Travel Award 2013
  • Melanie Kalbfleisch: International SDS Congress Travel Award 2013
  • David Liddle: Best Cell Biology Program Abstract prize. Research Institute Annual Summer Student Research Day 2011
  • Saswati Sen: International SDS Congress Travel Award 2009.
  • Saswati Sen: Department of Paediatric Research Day, The Hospital for Sick Children. Best Basic Science Poster  2009  
  • Saswati Sen: The Hospital for Sick Children Research Training Competition Award 2008-2009
  • Manveen Puri: Rising Stars in Research National Competition 2008
  • Saswati Sen: Ontario Graduate Scholarship Award 2008
  • Piya Rujkijyanont: Canadian Society of Haematology Abstract Competition Award 2007
  • Piya Rujkijyanont: American Society of Hematology Abstract Competition Award 2007
  • Ken-ichiro Watanabe: The Hospital for Sick Children Research Training Competition Award 2004-2005
  • Arif Manji: American Society of Hematology Travel Award 2003

Publications

Higgs C, Crow YJ, Adams DM, Change E, Hayes D Jr, Herbig U, Huang JN, Himes R, Jajoo K, Johnson FB, Reynolds SD, Yonekawa Y, Armanios M, Boulad F, DiNardo CD, Dufour C, Goldman FD, Khan S, Kratz C, Myers KC, Raghu G, Alter BP, Aubert G, Bhala S, Cowen EW, Dror Y, El-Youssef M, Friedman B, Giri N, Helms Guba L, Khincha PP, Lin TF, Longhurst H, McReynolds LJ, Nelson A, Olson T, Pariser A, Perona R, Sasa G, Schratz K, Simonetto DA, Townsley D, Walsh M, Stevens K, Agarwal S, Bertuch AA, Savage SA; Clinical Consortium for Telomere-associated Ailments (CCCTAA).  Understanding the evolving phenotype of vascular complications in telomere biology disorders.  Angiogenesis 2018   [Epub ahead of Print]

Shalata A, Lauhasurayotin S, Leibovitz Z, Dhanraj S, Moshiri H, Bakry H, Li H, Arad A, Hadid Y, Mahroum M, Herbert D, Egenburg S, Bajar J, Haddad H, Shohat M, Scherer S, Tzur S, Dror Y. Biallelic mutations in EXOC3L2 cause a novel syndrome that affects the brain, kidney and blood. J. Med Genet 2018 [Epub ahead of Print]

Arbiv OA, Cuvelier G, Klaassen RJ, Fernandez CV, Robitaille N, Steele M, Breakey V, Abish S, Wu J, Sinha R, Silva M, Goodyear L, Jardine L, Lipton JH, Corriveau-Bourque C, Brossard J, Michon B, Ghemlas I, Waespe N, Zlateska B, Sung L, Cada M, Dror Y.  Molecular analysis and genotype-phenotype correlation of Diamond-Blackfan anemia.  Clin Genet 2018;93(2):320-328.

Shabanova I, Cohen E, Cada M, Vincent A, Cohn RD, Dror Y.  ERCC6L2-associated inherited bone marrow failure syndromes. Mol Genet Genomic Med 2018;6(3):463-468

Dhanraj S, Matveev A, Li H, Lauhasurayotin S, Jardine L, Cada M, Zlateska B, Tailor CS, Zhou J, Mendoza-Londono R, Vincent A, Durie PR, Scherer SW, Rommens JM, Heon E, Dror Y. Biallelic mutations in DNAJC21 cause Shwachman-Diamond syndrome. Blood 2017;16(129):1557-62.

Waespe N, Dhanraj S, Wahala M, Tsangaris E, Enbar T, Zlateska B, Li H, Klaassen RJ, Fernandez CV, Cuvelier GDE, Wu JK, Pastore YD, Silva S,. Lipton JH, Brossard J, Michon B, Abish S, Steele M, Sinha R, Belletrutti MJ, Breakey VR, Jardine L, Goodyear L, Kofler L, Cada M, Sung L, Shago M, Scherer SW, Dror Y. The clinical impact of copy number variants in inherited bone marrow failure syndromes. Genomic Medicine 2017:10;2. doi: 10.1038/s41525-017-0019-2

Notta F, Zandi S, Takayama N, Dobson S, Gan OI, Wilson G, Kaufmann KB, McLeod J, Laurenti E, Dunant CF, McPherson JD, Stein LD, Dror Y, Dick JE. Distinct routes of lineage development reshape the human blood hierarchy across ontogeny. Science 2016;8;351.

Waespe N, Van Den Akker M, Klaassen RJ, Lieberman L, Irwin MS, Ali SS, Abdelhaleem M,Zlateska B, Liebman M, Cada M, Schechter T, Dror Y. Response to treatment with azacitidine in children with advanced myelodysplastic syndrome prior to hematopoietic stem cell transplantation. Hematologica 2016;101(12):1508-15.

Cada M, Segbefia C, Klaassen R, Fernandez CV, Yanofsky R, Wu J, Pastore Y, Silva M, Lipton JH, Brossard J, Michon B, Abish S, Steele M, Sinha R, Belletrutti M, Breakey V, Jardine L, Goodyear L, Sung S, Shago M, Sharma P, Zlateska B, Dror Y. The impact of the category, cytopathology and cytogenetics on development and progression of clonal and malignant myeloid transformation in inherited bone marrow failure syndromes. Haematologica 2015:100(5): 633-42.

Ghemlas I, Li H, Zlateska B, Klaassen R, Fernandez CV, Yanofsky RA, Wu J, Pastore Y, Silva M, Lipton JH, Brossard J, Michon B, Abish S, Steele M, Sinha R, Belletrutti M, Breakey VR, Jardine L, Goodyear L, Sung L, Dhanraj S, Reble E, Wagner A, Beyene J, Ray P, Meyn S, Cada M, Dror Y. Improving diagnostic precision, care and syndrome definitions using comprehensive next-generation sequencing for the inherited bone marrow failure syndromes. Journal of Medical Genetics 2015.

Dhanraj S, Gunja SM, Deveau AP, Nissbeck M, Boonyawat B, Coombs AJ, Renieri A, Mucciolo M, Marozza A, Buoni S, Turner L, Li H, Jarrar A, Sabanayagam M, Kirby M, Shago M, Pinto D, Berman JN, Scherer SW, Virtanen A, Dror Y. Bone marrow failure and developmental delay caused by mutations in poly(A)-specific ribonuclease (PARN). J Med Genet. 2015;52(11):738-48.

Williams DA, Bennett C, Bertuch A, Bessler M, Coates T, Corey S, Dror Y, Huang J, Lipton J, Olson TS, Reiss UM, Rogers ZR, Sieff C, Vlachos A, Walkovich K, Wang W, Shimamura A. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): An initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC). Pediatr Blood Cancer 2014: 61: 869-74.

Sen S, Wang H, Nghiem CL, Zhou K, Yau J, Tailor C, Irwin M, Dror Y.The ribosome-related protein, SBDS, is critical for normal erythropoiesis. Blood 2011:8;118(24):6407-17.

Dror Y, Donadieu J, Koglmeier J, Dodge J, Toiviainen-Salo S, Makitie O, Kerr E, Zeidler C, Shimamura A, Shah N, Cipolli M, Kuijpers T, Durie P, Rommens J, Siderius L, Liu JM, Shwachman-Diamond Syndrome: Consensus Guidelines. Ann N Y Acad Sci. 2011;1242(1):40-55.

Tsangaris E, Klaassen R, Fernandez CV, Yanofsky R, Shereck E, Champagne J, Silva M, Lipton JH, Brossard J, Samson Y, Abish S, Steele M, Ali K, Dower N, Athale U, Jardine L, Hand JP, Stephen D, Odame I, Canning P, Allen C, Carcao M, Beyene J, Roifman CM, Dror Y. Genetic analysis of inherited bone marrow failure syndromes from one comprehensive and population-based cohort and identification of novel mutations. J Med Genet. 2011; 48(9):618-28

Hashmi SK, Allen C, Klaassen R, Fernandez CV, Yanofsky R, Shereck E, Champagne J, Silva M, Lipton JH, Brossard J, Samson Y, Abish S, Steele M, Ali K, Dower N, Athale U, Jardine L, Hand JP, Beyene J, Dror Y. Comparative analysis of Shwachman-Diamond Syndrome to other Inherited Marrow Failure Syndromes. Clinic Genet 2010

Baker JM, Lewis VA, Fernandez CV, Duval M, Crooks BN, Yuille K, Freedman MH, Doyle JJ, Dror Y. Allogeneic hematopoietic stem cell transplantation of patients with FA and high risk features using fludarabine without radiation. Pediatr Blood Cancer 2009;52: 683-5.

Rujkijyanont P, Adams S, Beyene J, Dror Y. Bone marrow cells from patients with Shwachman-Diamond Syndrome abnormally express genes involved in ribosome biogenesis and RNA processing. Brit J Haematol 2009: 145:806-15.

Macartney C, Freilich M, Odame I, Charpentier K, Dror Y.   Complete response to tacrolimus in a child with severe aplastic anemia resistant to cyclosporine A. Pediatr Blood Cancer 2009;52:525-7.

Watanabe K, Ambekar C, Wang W, Ciccolini A, Schimmer A, Dror Y. SBDS-deficiency results in specific hypersensitivity to Fas stimulation and accumulation of Fas at the plasma membrane. Apoptosis 2009: 14:77-89.

Dror Y. Shwachman-Diamond syndrome: implications for understanding the molecular basis of leukaemia. Expert Rev Mol Med 2008: 10:1-10.

Tsangaris E, Adams SL, Yoon G, Chitayat D, Lansdorp P, Dokal I, Dror Y. Ataxia and pancytopenia caused by a mutation in TINF2. Human Genetics 2008: 124:507-13.

Ward AC, Gits J, Majeed F, Aprikyan AA, Lewis RS, O'Sullivan LA, Freedman M, Shigdar S, Touw IP, Dale DC, Dror Y: Functional interaction between mutations in the granulocyte colony-stimulating factor receptor in severe congenital neutropenia. Br J Haematol 2008:142:653-6.

Teo JT, Klaassen R, Fernandez CV, Yanofsky R, Wu J, Champagne J, Silva M, Lipton JH, Brossard J, Samson Y, Abish S, Steele M, Ali K, Dower N, Uma Athale, Jardine L, Hand JP, Tsangaris E, Beyene B, Dror Y: Clinical and genetic analysis of unclassifiable inherited bone marrow failure syndromes. Pediatrics 2008;122:139-48.

Rujkijyanont P, Watanabe KI, Ambekar C, Wang H, Schimmer AD, Beyene J, Dror Y: Sbds-deficient cells undergo accelerated apoptosis through the Fas-pathway and not through the Bax/Bcl2/BclXL pathway. Haematologica 2008:93;363-71.

Rosenberg PS, Alter BP, Link DC, Stein S, Rodger E, Bolyard AA, Aprikyan AA, Bonilla MA, Dror Y, Kannourakis G, Newburger PE, Boxer LA, Dale DC: Neutrophil Elastase Mutations and Risk of Leukemia in Severe Congenital Neutropenia. Brit J Haematol 2008:104;210-3.

Pongtanakul B, Das PK, Charpentier K, Dror Y. Outcome of children with aplastic anemia treated with immunosuppressive therapy. Pediatr Blood Cancer 2008:50:52-7.

Rujkijyanont P, Beyene J, Wei K, Kahn F, Dror Y: Leukemia-related gene expression in bone marrow cells from patients with the pre-leukemic disorder Shwachman-Diamond syndrome. Brit J Haematol 2007:137;537-44.

Calado RT, Graf SA, Wilkerson KL, Kajigaya S, Ancliff PJ,Dror Y, Chanock SJ, Lansdorp PM, Young NS: Mutations in the SBDS gene in acquired aplastic anemia. Blood 2007:110:1141-6.

Leung E, Rujkijyanont P, Beyene J, Wei K, Freedman J, Dror Y: Shwachman-Diamond Syndrome: an inherited model of aplastic anemia with increased angiogenesis. British Journal of Haematology. (British Journal of Haematology, Brit J Haematol 2006: 133:558-61.

Cheretakis C, Leung R, Sun CX, Dror Y, Glogauer M: Timing of neutrophil tissue repopulation predicts restoration of innate immune protection in a murine bone marrow transplant model. Blood 2006:108:2821-6.

Steele JM, Sung L, Klaassen R, Fernandez CV, Yanofsky R, Wu J, Odame I, Silva M., Champagne J, Ali, K, Brossard J, Samson Y, Abish S, Le D, Jardine L, Hand JP, Lipton JH, Charpentier K, Stephens D, Freedman M, Dror Y: Disease Progression in Recently Diagnosed Patients with Inherited Marrow Failure Syndromes: A Canadian Inherited Marrow Failure Registry (CIMFR) Report. Pediatr Blood Cancer 2006:47:918-25.

Dror Y: Shwachman-Diamond syndrome. Pediatr Blood Cancer 2005:45:892-901.

Majeed F, Jadko S, Freedman M, Dror Y: Mutation analysis of SBDS in pediatric acute myeloblastic leukemia with and without chromosome 7 abnormalities. Pediatr Blood Cancer 2005:45;920-4.

Dror Y, Gruenbaum E, Hitzler J, Narendran A, Ye C, Edwards V, Freedman M, Roifman C. Purine nucleoside phosphorylase deficiency associated with a dysplastic marrow morphology. Pediatr Res 2004:55:472-7.

Dror Y. The Role of Mitochondrial-Mediated Apoptosis in a Myelodysplastic Syndrome Secondary to Congenital Deletion of the Short Arm of Chromosome 4. Exp Hematol 2003;31:211-7.

Dror Y, Freedman MH, Leaker M, Verbeek J, Armstrong CA, Saunders FE, Doyle JJ. Nonmyeloablative hematopoietic stem-cell transplantation across human leukocyte antigen barriers in dyskeratosis congenita. Bone Marrow Transplant 2003;31:847-50.

Dror Y
, Durie P, Ginzberg H, Herman R, Banerjee A, Champagne M, Shannon K, Malkin D, Freedman MH. Clonal Evolution in Marrows of Patients with Shwachman-Diamond syndrome. Exp Hematol 2002;30:659-69.

Dror Y
, Freedman MH. Marrow cells from Shwachman-Diamond syndrome (SDS) patients are characterized by abnormally increased apoptosis mediated through the Fas pathway. Blood 2001;97:3011-6.

Dror Y, Leaker M, Caruana G, Bernstein A, Freedman MH: Mastocytosis cells bearing a c-kit activation mutation are characterized by hypersensitivity to stem cell factor and increased programmed cell death. Brit J Haematol 2000;108:729-36.

Dror Y, Ward A, Tauw I, Freedman MH. Combined corticosteroid/granulocyte colony-stimulating factor (G-CSF) therapy in the treatment of severe congenital neutropenia unresponsive to G-CSF. Exp Hematol 2000;28:1381-9.

Dror Y, Freedman MH. Shwachman-Diamond syndrome is an inherited pre-leukemic bone marrow failure disorder with aberrant hematologic progenitors and faulty marrow microenvironment. Blood 1999;94:3048-54.
 

Book Chapters

Dror Y. Inherited bone marrow failure disorders.  In: Hoffman’s Textbook of Hematology: Principles and Practice. 7th edition (Churchill Livingstone, Elsevier Ed) 2018

Dror Y, Cada M, Chapter 495. The Inherited Pancytopenias; Book Title: Nelson Textbook of Pediatrics 21st ed; Editors: Robert M. Kliegman, Joseph W. St. Geme, III; Associate Editors: Nathan J. Blum, Ivor Braden Horn, Samir S. Shah, Robert C. Tasker, Karen M. Wilson. 2018

Dror Y, Cada M. Severe Aplastic Anemia; Book Title: Bone Marrow Failure; Volume editors: Gary Kupfer, Gregory H. Reaman, Franklin O. Smith; Series: Pediatric Oncology; Volume number: yet to be assigned;  Publisher: Springer; 2017

Dror Y. The inherited pancytopenias. In: Nelson’s Textbook of Pediatrics. 21th Edition (Elsevier Saunders) 2015  

Dror Y, Chan A, Avila L, Baker J: Pathophysiology and Management of the Newborn. In: Avery’s Textbook of Neonatology. (6th Edition). MacDonald M, Seshia MMK, Mullett MD (Eds), Lippincott Williams & Wilkins, Philadelphia PA, June 20146. 

Dror Y, Freedman F. Inherited bone marrow failure disorders.  In: Hoffman’s Textbook of Hematology: Principles and Practice. 6th edition (Churchill Livingstone, Elsevier Ed) 2012  

Dror Y, Freedman F. The inherited pancytopenias. In: Nelson’s Textbook of Pediatrics. 20th Edition (Elsevier Saunders) 2012

Dror Y. Inherited bone marrow failure syndromes: genetic complexity of monogenic disorders. In: Genetic Disorders. InTech Open Access Publisher 2011.

Dror Y: Inherited Bone Marrow Failure Syndromes.  In:  Pediatric Hematology 3e (Arececi, Hann & Smith, eds).  Blackwell Publishing, Oxford 2006: pp 30-36. 

Teo J, Dror Y: Acquired Aplastic Anemia.  In:  Pediatric Hematology 3e (Arececi, Hann & Smith, eds).  Blackwell Publishing, Oxford 2006: pp 64-76.

Blanchette VS, Chan A, Dror Y: Neonatology Hematology.  In:  Textbook of Neonatology: Pathophysiology and Management of the Newborn.  6th Edition (MacDonald MG, ed).  Lippincott Williams & Wilkins, Philadelphia 2005: pp 1169-1234.

Dror Y, Sung L: Update on childhood neutropenia: Molecular and clinical advances.  In:  Hematology/ Oncology Clinics of North America (Buchanan G, ed).  W.B. Saunders Company, 2004: pp 1439-1458.