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Rovet Lab

Studies under analysis

Thyroid Hormone in Pregnancy (TIPS) Studies 1 and 2

Thyroid Hormone in Pregnancy (TIPS) Studies 1 and 2

Purpose: To examine cognitive abilities in infants and children exposed to insufficient thyroid hormone during pregnancy or early life.

Subjects: Five groups of infants and children were assessed: offspring of women with hypothyroidism during pregnancy, offspring of women with hyperthyroidism during pregnancy, children with low-risk prematurity, children with congenital hypothyroidism, typically developing controls. Over 300 children initially participated.

Approach: All children were recruited during or shortly after birth and assessed at 6, 12, and 18 months (TIPS1) and at 5 years of age (TIPS2). Infants were assessed using standardized neurodevelopmental tests and computer tests of infant attention and memory. 5-year olds were assessed with an extensive battery of neuropsychological tests

Status: Testing completed; publications underway.

Funding Sources: March of Dimes (U.S.), Canadian Institutes of Health Research, Abbott Pharmaceuticals TRAC Grant.


Thyroid Hormone in Pregnancy Study 3A

Thyroid Hormone in Pregnancy Study 3A

Purpose: To evaluate visual abilities of infants exposed to insufficient thyroid hormone during pregnancy or early life.

Subjects: Four infant groups: offspring of women with hypothyroidism during pregnancy; children with low-risk prematurity born 33-35 weeks gestation, children with congenital hypothyroidism (CH), typically developing controls. Approximately 80 infants participated.

Approach: All children were recruited during or shortly after birth and assessed at 3, 4.5, and 6 months of age. Infants were assessed electrophysiologically with a sweep VEP technique, which measured visual acuity and contrast sensitivity.

Findings: Results showed reduced contrast sensitivity in maternal hypothyroid and CH groups and a trend for reduced visual acuity in the preterm group. Contrast sensitivity deficit was correlated with severity of thyroid hormone deficiency in maternal hypothyroid and CH groups. Results are published in Pediatrics Research.

Status: Completed

Funding Sources: Canadian Institutes of Health Research


Thyroid Hormone in Pregnancy Study 3B

Thyroid Hormone in Pregnancy Study 3B

Purpose: To evaluate visual abilities of infants exposed to insufficient thyroid hormone during pregnancy or early life.

Subjects: Three infant groups: offspring of women with hypothyroidism during pregnancy, offspring of women with hyperthyroidism during pregnancy, typically developing controls. Approximately 80 infants participated.

Approach: All children were recruited during or shortly after birth and assessed electrophysiologically at 6 months of age using (a) sweep VEP technique to measure visual acuity and contrast sensitivity and (b) transient VEPs to measure color vision. Contrast sensitivity was assessed at varying temporal