Seema Mital

Dr. Seema Mital completed her paediatric residency at Children’s Hospital of Michigan in 1996 and a fellowship in Paediatric Cardiology in 1999 from Columbia University, New York, USA. Mital was Assistant Professor at Columbia University, Morgan-Stanley Children’s Hospital of New York, until 2007 when she joined SickKids as a staff cardiologist in the Heart Function and Transplant Program.

Mital serves on the executive committees of the SickKids Labatt Family Heart Centre, the Heart and Stroke Richard Lewar Centre of Excellence, the Ted Rogers Centre for Heart Research, and the Canadian Heart Function Alliance. She is also a fellow of the American Heart Association and serves on the Scientific Publications Committee, as well as the Strategic Outcomes Committee.

Research

Mital leads the Cardiac Precision Medicine Program of the Ted Rogers Centre for Heart Research at SickKids. Her research in cardiac precision medicine leverages genomics, stem cells, AI and digital technology to model disease, test therapies, and implement precision-focussed decision support tools. Mital established the SickKids Heart Centre Biobank, a multi-centre biorepository for childhood onset heart disease, one of the largest international repositories of its kind. Mital leads the ERAPerMed/CIHR funded PROCEED network for Personalized Genomics in congenital heart disease, leads the multi-centre international Precision Medicine in Cardiomyopathy (PRIMACY) network, as well as the CIHR-funded INSERT-HCM study.

Education and experience

• 1996–1999: Fellowship, Paediatric Cardiology, Columbia University, New York, NY, USA
• 1995–1996: Research Fellowship, Neonatology, Children’s Hospital of Michigan, Detroit, MI, USA
• 1993–1996: Residency, Paediatrics, Children’s Hospital of Michigan, Wayne State University, Detroit, MI, USA

Achievements

• 2022: Faculty Recognition Award for Strong Citizenship, Insitute of Medical Science, University of Toronto
• 2020: Co-recipient, Janet Rossant Research Innovation Prize for Precision Health Resource of Control iPSC Lines for Versatile Multilineage Differentiation

1. Lesurf R*, Said A*, Akinrinade O, Breckpot J*, Delflosse K, Liu T, Yao R, Persad G, McKenna F, Noche RR, Oliveros W, Mattioli K, Shah S, Miron A, Yang Q, Meng G, Yue MCS, Sung WWL, Thiruvahindrapuram B, Lougheed J, Oechslin E, Mondal T, Bergin L, Smythe J, Jayappa S, Rao VJ, Shenthar J, Dhandapany PS, Semsarian C, Weintraub RR, Bagnall RD, Ingles J, Genomics England Research Consortium, Mele M, Maass PG, Ellis J, Scherer SW, Mital S. Whole genome sequencing delineates regulatory, copy number and cryptic splice variants in early onset cardiomyopathy. (*co-first authors). Nature Portfolio Journal Genomic Medicine. 2022: 7 (1): pp 18. (Mar).
2. Miron A, Lafreniere-Roula M, Fan CP, Armstrong K, Dragulescu A, Papaz T, Manlhiot C, Kaufman B, Butts R, Gardin L, Stephenson E, Howard T, Aziz P, Balaji S, Beauséjour –Ladouceur V, Benson L, Colan S, Godown J, Henderson H, Ingles J, Jeewa A, Jefferies J, Lal A, Mathew J, Jean-St-Michel E, Michels M, Nakano S, Olivotto I, Parent J, Pereira A, Semsarian C, Whitehill R, Wittekind S, Russell M, Conway J, Richmond M, Villa C, Weintraub R, Rossano J, Kantor P,Y. Ho C, Mital S. A validated model for sudden cardiac death risk prediction in pediatric hypertrophic cardiomyopathy. Circulation 2020: 142 (3): pp 217 – 229.
3. Ommen SR, Mital S (Vice-Chair), Burke MA, Day SM, Deswal A, Elliott P, Evanovich LL, Hung J, Joglar JA, Kantor P, Kimmelstiel C, Kittleson M, Link MS, Maron MS, Martinez MW, Miyake CY, Schaff HV, Semsarian C, Sorajja P. 2020 AHA/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Journal of the American College of Cardiology. 2020: 76 (25): pp e159 – e240.
4. Shaddy RE, Cetta F, Feltes TF, Penny DJ, Mital S. Moss and Adams’ Heart Disease in Infants, Children and Adolescents, 10th Edition. Vol 1: pp 1 – 982, Vol 2: pp 983 – 1823.
5. Turki SA*, Manickaraj AK*, Mercer CL*, Gerety S*, Hitz M-P, Lindsay S, D'Alessandro LCA, Swaminathan GJ, Bentham J, Arndt A-K, Breckpot J, Low J, Thienpont B, Abdul-Khaliq H, Harnack C, Hoff K, Kramer H-H, Schubert S, Siebert R, Toka O, Cosgrove C, Watkins H, Lucassen AM, O’Kelly IM, Salmon AP, Bu’Lock FA, Granados-Riveron J, Setchfield K, Thornborough C, Brook JD, Mulder B, Klassen S, Bhattacharya S, DeVriendt K, FitzPatrick D, UK10K, Wilson DI, Mital S†, Hurles ME†.. Rare variants in NR2F2 cause congenital heart defects in humans. Amer J Human Genetics. 2014. 94 (4): pp 574 – 578. (* Co-first authors; † Co-corresponding authors).

View a full list of Seema Mital's publications in PubMed

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