Facebook Pixel Code
Section banner image
Paediatric Laboratory Medicine

Ibuprofen

Clinical Significance

Ibuprofen is classified with the Nonsteroidal Anti-inflammatory Agents. It is grouped with the Propionic acid derivitives along with Fenoprofen and Naproxen. The major effect of the NSAID's is to decrease the synthesis of prostaglandins by inhibiting the enzyme cyclooxygenase. Prostaglandins enhance the inflammatory response, renal blood flow and cytoprotection of the GI mucosa.  Ibuprofen is metabolized in man by oxidation of the isobutyl group resulting in two major metabolites: 2-hydroxyibuprofen and 2-carboxyibuprofen. Toxicity symptoms include: headache, tinnitus, drowsiness, nausea and abdominal pain. Severe toxicity is reported mainly in children and symptoms may include: seizures, apnea, hypertension and renal and hepatic dysfunction.

Test Name

Ibuprofen

Alternate Name/ Synonym

Motrin, Advil

Test Code

IBUPB

Drug Class

Analgesic

Division

Toxicology

Method

HPLC

External Proficiency Testing

KKGT - Netherlands (Association for Quality Assessment in Therapeutic Drug Monitoring and Clinical Toxicology)

Turn Around Time

Daily, Stat

Specimen Type

Serum, Plasma (Heparin, Citrate or EDTA)

Minimum Specimen Requirements

600 uL

Optimal Collection Time

NA

Storage/Transportation

4°C (transport with a cool pack if possible)

Special Requirements

NA

Approval is not required

CPT Codes

80299

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Therapeutic Range

Not detected

Critical Values

Refer to Hall Nomogram