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Paediatric Laboratory Medicine

Cortisol, Blood

Clinical Significance

Cortisol measurements are used as a direct monitor of adrenal status and an indirect measure of pituitary hyper or hypofunction. Elevated cortisol levels are associated with adrenal tumors, pituitary tumors or ectopic ACTH-producing tumors. Subnormal cortisol concentrations may indicate generalized adrenal hypofunction or a defect in the metabolic pathway for cortisol biosynthesis.

Test Name

Cortisol, Blood

Test Code

SPCORT

Division

Biochemistry - Biochemistry

Method

LC-MS/MS

External Proficiency Testing

CAP, QMPLS, KKGT - Netherlands (Association for Quality Assessment in Therapeutic Drug Monitoring and Clinical Toxicology)

Turn Around Time

Tuesday to Thursday

Specimen Type

Serum, Sodium/Lithium Heparin, K EDTA plasma, Urine

Minimum Specimen Requirements

400 uL

Storage/Transportation

Frozen

Approval is not required

CPT Codes

82533

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Reference Range

Age

Range (nmol/L)

1 – 14d

13 – 340

15d – 11m

14 – 458

1 – 8y

48 – 297

9 – 13y

61 – 349

14 – 16y

77 – 453

17 – 18y

97 – 406

Adult

See attachment