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Paediatric Laboratory Medicine

Estradiol (Sensitive), Blood

Clinical Significance

Estradiol is the most potent natural estrogen in humans. It regulates  reproductive function in females, and, with progesterone, maintains pregnancy. Most estradiol is secreted by the ovaries (non-pregnant women), although the testes (in men) and adrenal cortex (in men and women) secrete small amounts. During pregnancy, the placenta produces most of the circulating estradiol. Monitoring estradiol levels is essential during in vitro fertilization, because the timing of recovery of oocytes depends on follicular development, which in turn depends on the estradiol level

Test Name

Estradiol (Sensitive), Blood

Test Code

ESTD

Division

Biochemistry - Biochemistry

Method

RIA

External Proficiency Testing

CAP
QMPLS

Turn Around Time

Every 2'nd week

Specimen Type

Serum, Sodium/Lithium Heparin / EDTA plasma

Minimum Specimen Requirements

500 uL

Approval is not required

CPT Codes

82670

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Reference Range

Males: Poorly defined: Levels fall from about 246 pmol/L at birth to <60 pmol/L at 1 yr.
1 yr to adrenarche : <60 pmol/L.
Puberty: rising to adult level <109 pmol/L.

Females: Poorly defined  Levels fall from about 246 pmol/L at birth to <60 pmol/L at 1 yr.
1 yr to adrenarche : <60 pmol/L.
Adrenarche through puberty: rising to adult level ,correlating with pubertal stage and phase of cycle (>60 pmol/L).
Adrenarche through puberty: rising to adult level ,correlating with pubertal stage and phase of cycle (>60 pmol/L)
Adult: Follicular phase 72 - 121 pmol/L.
Luteal phase 367 - 564 pmol/L.
Treated with synthetic estrogens <109 pmol/L.