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Paediatric Laboratory Medicine

Testosterone, Blood

Clinical Significance

Testosterone is produced by the adrenals, the theca cells in the ovary and the leydig cells in the testes. As much as 97% of circulating testosterone is bound to serum proteins such as sex hormone binding globulin (SHBG). In the male, testosterone stimulates the maturation of genitalia and secondary sexual characteristics and its measurement is used to investigate sexual dysfunction in juveniles and adults. In females testosterone concentrations are much lower and an elevated concentration may indicate polycystic ovarian syndrome among other conditions. Clinical symptoms of testosterone excess in females include infertility, amenorrhea, obesity and hirsutism.

Test Name

Testosterone, Blood

Test Code

SPTES

Division

Biochemistry - Biochemistry

Method

LC-MS/MS

External Proficiency Testing

CAP, QMPLS, KKGT - Netherlands (Association for Quality Assessment in Therapeutic Drug Monitoring and Clinical Toxicology)

Turn Around Time

Tuesday & Thursday

Specimen Type

Serum, Sodium/Lithium Heparin / K EDTA plasma

Minimum Specimen Requirements

300 uL

Storage/Transportation

Frozen

Approval is not required

CPT Codes

84403

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Reference Range

Female

Age

Range (nmol/L)

0 – <14d

0.1 – 0.4

15d – <1y

0.0 – 0.2

1 – <13y

0.1 – 1.1

13 – <16y

0.5 – 1.4

16 – <19y

0.1 – 2.3

Adult

See attachment

Male

Age

Range

0 – <14d

0.3 – 6.4

15 – <1y

0.1 – 8.9

1 – <13y

0.1 – 1.1

13 – <16y

1.0 – 15.7

16 – <19y

 0.9 – 23.4

Adult:

See attachment