Current Research Interests
The Rossant lab aims to understand the genetic underpinning of early lineage development in the mouse embryo in order to
understand embryo development and stem cell origins.
Ongoing research topics can be grouped into several specific areas:
Early patterning decisions in the mouse embryo
- Katie Cockburn: Molecular mechanisms underlying trophectoderm specification
- Fredrik Lanner: Lineage specification in the developing blastocyst
- Rob Stephenson: Understanding the origins of the first 3 cell lineages in the mouse
- Lingyu Li: Identification of ectodermal cells during early mouse embryonic development and EpiSC differentiaton
Specification of cell lineages
- Steffen Biechele: Roles of the X-chromosomal Porcupine gene in Wnt signaling, mouse embryonic development and human disease
- Lamis Hammoud: Identifying and characterizing novel modulators of blood vessel formation using embryonic stem cells
- Rita Silva: Embryonic gut formation
- Xin Sun: Chromatin remodeling and transcription factors in early cardiac development
- Oliver Tam: Dissecting the regulatory network of trophoblast stem (TS) cell development
Stem cell differentiation
- Melanie Bilodeau: Molecular pathways regulating lung epithelial differentiation
- Angela McDonald: Molecular regulation of the definitive endoderm and its derivatives
- Amy Wong: Establishment and study of cystic fibrosis-patient derived iPS cells