MethylationEPIC Assay
Methylation Based Tumour Classification and Copy Number Profiling
DNA based assay - Illumina MethylationEPIC Assay
Tumour Tissue - 40 mg of frozen tissue or 10 x 10 FFPE micron sections or FFPE Block
The tissue provided must be representative of the tumour
• One H&E stained slide representative of the tested tissue should be provided
• DNA based assay
To avoid compromising specimen integrity, ship Monday through Wednesday only.
Do not ship specimen on the day of or the day before a Canadian statutory holiday.
Canadian Holidays to consider:
• New Year’s Day – January 1
• Good Friday – the Friday before Easter
• Victoria Day – Monday on or before May 24
• Canada Day – July 1
• Civic Holiday – First Monday in August
• Labour Day – First Monday in September
• Thanksgiving – Second Monday in October
• Christmas Day – December 25
• Boxing Day – December 26
SNAP FROZEN TISSUES.
• All frozen tissues must be shipped on dry ice.
• Specimen must be sent Monday through Wednesday only.
• Never place samples directly on the dry ice.
• We recommend a minimum of 4 kg (approx. 10 lbs.) of dry ice for international shipments.
• Do not over-pack. Over-packed Styrofoam will crack and dry ice will be consumed faster.
• Regulations require that the diamond shaped dry ice sticker be placed on the outside of the shipping box.
PARAFFIN SCROLLS.
• Scrolls from FFPE tissues can be shipped at room temperature.
• Scrolls must be shipped immediately after shaving.
PARAFFIN BLOCKS.
• Block(s) from FFPE tissues can be shipped at room temperature.
To avoid shipping problems:
• To schedule a shipment, contact a freight forwarder who knows how to export medical specimens from your country.
• Ask the forwarder to help you with local regulations, completing the necessary documentation and arranging to clear the shipment through
Canada Customs.
• Transit times may be more than one day. Please take this into account when packaging your samples.
The Infinium MethylationEPIC BeadChip Kit is a genome-wide methylation screening tool that targets over 935,000 CpG sites in the most biologically significant regions of the human methylome. This is a DNA-based assay that enables tumour classification through analysis with tumour classifier algorithms as well as copy number variation and MGMT methylation.
CNS tumour: classification and copy number profiling
Sarcoma: classification and copy number profiling
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