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SickKids

SickKids Research Institute

Driving clinical impact with every
research question

SickKids Research Institute (RI) is where over 2,000 researchers, trainees, and staff are working together to take on the toughest challenges in child health. As Canada’s largest, hospital-based child health research institute, we conduct and translate groundbreaking research to improve child health outcomes, policy, and clinical care, train the next generation of researchers, and support global scientific communities with knowledge and state-of-the-art facilities.  

Innovation and collaboration across our seven distinct research programs have led to a number of incredible discoveries at SickKids, uncovering the mechanisms and outcomes of childhood disease. And with every research question in the lab, we are driving clinical changes.

By challenging existing care models and maximizing research translation, we’re taking more discoveries from the lab bench to the bedside, making a bigger impact on children’s lives around the world, sooner.

By the numbers

276 scientists

1,018 research trainees

394 project & team investigators

1,126 research support staff

$262.6M research spend

2,099 publications

Award

#1 research intensity among Canadian hospitals

#2 among Canada's top research hospitals in total research spending

Explore the Institute

Our Researchers

Meet the researchers working across the spectrum of child health, from basic science at the sub-molecular level, to clinical diagnostics, treatments and prevention.

Our Labs

Browse a list of labs to learn more about the exciting research taking place at SickKids Research Institute.

Two staff members having a discussion while seated at a table with a laptop and notebook open

Research Training Centre

The Research Training Centre offers trainees hands-on opportunities to contribute to some of the most important research projects in Canada and to work with top scientists.

Staff member sits in front of a microscope while looking at a scientific image on a nearby computer screen

Core Facilities

Learn about our cutting-edge equipment and infrastructure that’s powering new innovation and advancements in care.

Adolescent sits in a chair wearing a headband connected to a laptop with wires while an adult is standing behind her adjusting this headband

Participate in Clinical Research

As one of Canada's top research hospitals, families that walk through our doors have a chance to participate in clinical research to help address our greatest health challenges.

Clinical Research Services

Clinical Research Services supports quality clinical research by providing research facilities, tools, education and services for SickKids staff and researchers worldwide.

Latest research news

Macrophages and mesenchymal cells surrounded by a group of gut stem cells

December 5, 2022

Study uncovers relationship between stem cell development and gut microbes in newborn health

New SickKids research identifies key immune and microbial factors in the gut that influence newborn stem cell development, with implications for the treatment of necrotizing enterocolitis.

A graphic showing how a cancerous cell has 3x more RNA output than a normal cell.

November 28, 2022

Researchers develop novel algorithm to unlock role of cellular phenomenon in aggressive cancers

SickKids researchers develop an innovative computational method called RNAmp to measure hypertranscription in human tumours, with novel implications for cancer care.

Greg Wasney stands surrounding by research instruments in the SBC Facility.

November 24, 2022

How one SickKids core facility is breaking down the barriers to scientific collaboration

The Structural & Biophysical Core Facility is a centralized hub of state-of-the-art research instruments and expertise where scientists collaborate to advance paediatric medicine.

Research programs

Discover what our researchers are working on across SickKids' seven research programs that cover the spectrum of child health.

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Cell Biology

Cutting-edge methods in cell and molecular biology, biochemistry, and microscopy allow us to understand how cells function, and how these functions go awry in disease states.

Visit Cell Biology

Child Health Evaluative Sciences Research Program icon

Child Health Evaluative Sciences

By conducting and translating research into clinical practice, system, and policy, this research aims to improve the health and well-being of children and their families.

Visit Child Health Evaluative Sciences

Developmental and Stem Cell Biology Research Program icon

Developmental & Stem Cell Biology

Using development genetics, genomics, and stem cell biology, these research teams are developing new therapeutic approaches for children and youth.

Visit Developmental & Stem Cell Biology

Genetics and Genome Biology Research Program icon

Genetics & Genome Biology

Next-generation genomic sequencing tools are revolutionizing our understanding of disease and approaches to science.

Visit Genetics & Genome Biology

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Molecular Medicine

Researchers are developing new molecular approaches for the prevention, diagnosis, and treatment of human diseases.

Visit Molecular Medicine

Neurosciences and Mental Health Research Program icon

Neurosciences & Mental Health

This research focuses on advancing understanding of the brain to develop novel approaches to therapy and prevention strategies.

Visit Neurosciences & Mental Health

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Translational Medicine

Multidisciplinary teams across SickKids are blending their expertise to facilitate new clinical and biological ideas.

Visit Translational Medicine

More from the Research Institute

Canada Research Chairs showcase the calibre and diversity of scientists and clinicians working at the SickKids Research Institute.

View Canada Research Chairs

SickKids is home to 48 scientific and academic chairs. See who holds current chairs in Canada.

View Chairs

Led by internationally-recognized leaders in research, the SickKids Scientific Advisory Board (SAB) guides the strategic direction for the RI, establishes and monitors KPIs, and leads external reviews of the seven SickKids research programs.

Board Members

Professor Rosalind Smyth

  • Director and Professor of Child Health, UCL Great Ormond St Institute of Child Health 

Rosalind Smyth is Director of the UCL Great Ormond Street Institute of Child Health, Honorary Consultant Respiratory Paediatrician at Great Ormond Street Hospital and Non-Executive Director of Great Ormond Street Hospital NHS Foundation Trust.

Her current research interest  include clinical studies of viral/host interactions in RSV bronchiolitis, clinical trials and systematic reviews of treatments for childhood respiratory disease. Smyth previously served as Professor of Paediatric Medicine at The University of Liverpool UK and held the position of Director of the UK Medicines for Children Research Network, which supports a variety of paediatric research with children across all of England.

The Research Institute is currently seeking new members for the Scientific Advisory Board.

Research Awards & Financial Services (RAFS) supports researchers through the grant lifecycle, from grant applications and contract management, to monitoring and financial reporting.

Learn About RAFS

Contact the Research Institute

For all inquiries about SickKids Research Institute, please contact Jelena Djurkic, Manager, Communications (Research Institute & Strategic Initiatives), Communications & Public Affairs

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