Alpha-1-Acid glycoprotein (AAG), plasma or serum

Alternate test name

Orosomucoid , A1AGP

Lab area

Clinical Biochemistry - General

Method and equipment

Equipment: Roche Cobas Pro c503

Method: Immunoturbidimetric assay. Anti‑α1‑acid glycoprotein antibodies react with antigen in the sample to form an antigen/antibody complex. Following agglutination, this is measured turbidimetrically.

Expected turn-around time

STAT/ Urgent/ Routine: 24 Hours

Specimen type

Serum or plasma

Specimen requirements

SST Tube preferred, PST Tube is acceptable

Storage and transportation

Shipping information

The Hospital for Sick Children

Rapid Response Laboratory

555 University Avenue, Room 3642

Toronto, ON

Canada

M5G 1X8

Phone: 416-813-7200

Toll Free: 1-855-381-3212

Hours: 7 days/week, 24 hours/day

Requisition

Alpha-1-Acid glycoprotein (AAG), plasma or serum - requisition

Background and clinical significance

A1-acid glycoprotein (AGP, orosomucoid) is an acute-phase protein.

Elevated serum levels of A1-acid glycoprotein have been reported in acute and chronic inflammatory conditions, such as myocardial infarction, rheumatoid arthritis, systemic lupus erythematosus, Crohn's disease, chronic renal failure, injuries, burns, and malignancies.

Decreased serum levels of A1-acid glycoprotein can be found in malnutrition, in severe liver damage as well as in women using oral contraceptives (estrogens).