Anti-Liver Kidney Microsomal Antibody

Alternate test name

LKM, ALKM, anti-LKM

Lab area

Clinical Biochemistry - Immunology

Method and equipment

Indirect immunofluorescence (IFA), HEp-2 cell substrate

Expected turn-around time

7 days

Specimen type

Serum

Specimen requirements

Send 0.3 mL for 1 test or 0.6 mL min for several tests from:

ANA, HEp-2 IgG
ANCA, IgG
EMA, IgA
GBM, IgG
LKM, IgG
PCA, IgG
SMA, IgG
dsDNA, IgG (Cithidia luciliae)

Storage and transportation

Frozen

Shipping information

The Hospital for Sick Children

Rapid Response Laboratory

555 University Avenue, Room 3642

Toronto, ON

Canada

M5G 1X8

Phone: 416-813-7200

Toll Free: 1-855-381-3212

Hours: 7 days/week, 24 hours/day

Requisition

Anti-Liver Kidney Microsomal Antibody - requisition

Background and clinical significance

An anti-LKM antibody (anti–liver-kidney microsomal antibody or LKM antibody) is any of several autoantibodies that are detected in the serum of patients with different types of acute or chronic liver disease. These antibodies are targeted against antigens of the cytochrome P450 system. ALKM are also used in the diagnosis of autoimmune hepatitis.