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Valproate, plasma or serum

Alternate test name

Valproic Acid, Depakene, Epival

Lab area
Clinical Biochemistry - TDM & Toxicology
Method and equipment
Abbott Architect ci-4100
Expected turn-around time
Stat/ Urgent/ Routine: 2 hours
Specimen type

Serum, Plasma (Heparin)

Specimen requirements

150 uL

Storage and transportation

4°C (transport with a cool pack if possible)

Shipping information
The Hospital for Sick Children
Rapid Response Laboratory
555 University Avenue, Room 3642
Toronto, ON
M5G 1X8
Phone: 416-813-7200
Toll Free: 1-855-381-3212
Hours: 7 days/week, 24 hours/day
Background and clinical significance
Valproic acid is used in the treatment of patients with complex partial seizures which occur either alone or in association with other types of seizures. Valproic acid may be used solely or in combination with other anticonvulsant drugs. The capability of treating many different types of seizures has resulted in the wide-spread use of valproic acid, particularly in children. Most patients receiving valproic acid do not develop a tolerance to its anticonvulsant effects. Valproic acid is generally well tolerated, with the most common side effects being: headache, gastrointestinal (nausea, vomiting, diarrhea), nervous system (tremors) and thrombocytopenia.
Disease condition


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