Anti-Cardiolipin Antibody, IgG and IgM

Alternate test name

ACL, ACA, Anti-Phospholipid Antibody

Lab area

Clinical Biochemistry - Immunology

Method and equipment

Chemiluminescent immunoassay on the BIO-Flash analyzer (Werfen)

Expected turn-around time

10 days

Specimen type

Serum

Specimen requirements

Send: 0.3 mL for 1 test or 0.6 mL min for several of:

aCL
dsDNA
tTG (IgA)
MPO
PR3
anti-SM
SSb
Ro52
Ro60
RNP

Storage and transportation

Frozen

Shipping information

The Hospital for Sick Children

Rapid Response Laboratory

555 University Avenue, Room 3642

Toronto, ON

Canada

M5G 1X8

Phone: 416-813-7200

Toll Free: 1-855-381-3212

Hours: 7 days/week, 24 hours/day

Requisition

Anti-Cardiolipin Antibody, IgG and IgM - requisition

Background and clinical significance

Anti-cardiolipin (aCL) antibodies belong to a heterogeneous family of antiphospholipid (aPL) antibodies, which are autoantibodies directed against anionic phospholipids or protein-phospholipid complexes. Persistently elevated levels of aPL antibodies are associated with an increased risk for vascular thrombosis and obstetrical complications.