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Paul Frankland

Title:
Senior Scientist, Neurosciences & Mental Health
Designations:
PhD
Alternate Contact Name:
Lisa Alano
Alternate Email:
lisa.alano@sickkids.ca
U of T Positions:
Professor, Departments of Psychology, Physiology, Institute of Medical Science
Chair Positions:
Canada Research Chair, Tier 1

Biography

Paul Frankland is a Senior Scientist in the Neurosciences & Mental Health Program at SickKids Research Institute. He holds a Canada Research Chair in Cognitive Neurobiology, and is appointed as a Full Professor in the Department of Psychology, Department of Physiology, and Institute of Medical Science at the University of Toronto.

He is a Fellow of the Royal Society of Canada, and a member of the Canadian Institute for Advanced Research (CIFAR) in the program for Child and Brain Development. 

Research

Dr. Frankland’s research program combines behavior, imaging and molecular approaches to understand the neurobiological basis of memory. His team’s empirical and theoretical papers have advanced our understanding of systems consolidation, hippocampal neurogenesis and memory function, engrams, hippocampal memory development and developmental disorders.

To help accomplish the goal of understanding how the brain uses information, they combine a variety of tools, including optogenetics, chemogenetics and detailed behavioral analysis.

Education and experience

  • 1989: BA University of Sheffield
  • 1996: PhD University of Toronto
  • 1996–1998: Postdoctoral fellow, Cold Spring Harbor Laboratory, NY
  • 1998–2003: Postdoctoral fellow, UCLA, CA

Achievements

  • 2018: Fellow of the Royal Society of Canada

Publications

  1. Steadman, P.E., Xia, F., Ahmed, M., Steenland, H.W., Mocle, A.J., Penning, A.R.A., Geraghty, A.C., Monje, M., Josselyn, S.A. and Frankland, P.W. (2020).  Disruption of oligodendrogenesis impairs memory consolidation in adult mice. Neuron, 105, 150-164.
  2. Vetere, G., Tran, L.M., Moberg, S., Steadman, P.E., Restivo, L., Morrison, F.G., Ressler, K.J., Josselyn, S.A. and Frankland, P.W. (2019). Memory formation in the absence of experience. Nature Neuroscience, 22, 933-940.  
  3. Vetere, G.*, Kenney, J.W.*, Tran, L.M., Xia, F., Steadman, P.E., Parkinson, J., Josselyn, S. A. and Frankland, P.W. (2017). Chemogenetic interrogation of a brainwide fear memory network in mice. Neuron, 94, 363-374. 
  4. Akers, K.G.*, Martinez-Canabal, A.*, Restivo, L.*, Yiu, A.P., de Cristofaro, A., Hsiang, H-L., Wheeler, A.L., Guskjolen, A., Niibori, Y., Shoji, H., Ohira, K., Richards, B.A., Miyakawa, T., Josselyn, S.A. and Frankland, P.W. (2014). Hippocampal neurogenesis regulates forgetting during adulthood and infancy. Science, 344, 598-602.
  5. Kee, N.*, Teixeira, C.M.*, Wang, A.H. and Frankland, P.W. (2007). Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nature Neuroscience, 10, 355-362. 

View a full list of Paul Frankland's publications

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