Eyal Grunebaum
Hospital Positions
- Clinician – Division of Immunology and Allergy
- Director – Advanced Immunology Management
- Member – Research Ethics Board
Research Positions
Senior Scientist – Developmental and Stem Cell Biology
Biography
Dr. Grunebaum obtained his medical degree at the Hebrew University, Jerusalem, Israel. After completing paediatric residency at the Schneider’s Children Medical Center in Israel, he pursued a clinical and research fellowship in immunology and allergy as well as haematopoietic stem cell transplantations at The Hospital for Sick Children (SickKids) in Toronto.
Dr. Grunebaum joined SickKids as a clinician scientist, focusing on the diagnosis, management and understanding of immune abnormalities in children and adults. Using diverse methods, including population studies, cell and animal models, Dr. Grunebaum has contributed to the identification of novel immune defects, development of novel therapies and better appreciation of the immune system in various health and disease states.
Research
Dr. Grunebaum’s research focuses on the immune system in healthy and sick children and adults. Using diverse methods, including population studies, cell and animal models, Dr. Grunebaum studies novel treatments for those born with a faulty immune system that can lead to conditions ranging from severe combined immune deficiency (known as “bubble babies”), children unable to produce appropriate antibodies to fight bacteria and viruses, to teenagers and adults with autoimmune and malignancy diseases.
Additionally, Dr. Grunebaum investigates causes and management of food allergy and anaphylaxis that occur spontaneously of after various interventions that affect the immune system. Dr. Grunebaum is currently working also on developing better gene and enzyme replacement therapies as well as transplantations of cells capable of reconstituting the immune system.
Education
- 1998–2001: Clinical and Research fellowship in paediatric immunology and allergy, Division of Allergy & Immunology/ Blood and Marrow Transplant Unit, The Hospital for Sick Children, Toronto
- 1994–1998: M.Sc. (Pediatrics), Sackler Faculty of Medicine, School of Continuing Medical Education. Tel-Aviv University, Tel-Aviv, Israel.
- 1992–1998: Residency in Pediatrics, Hasharon Hospital and Schneider’s Children’s Medical Center, Israel.
- 1986–1987: Internship, Soroka Medical Center, Beer Sheva and Belinson Medical Center, Israel.
- 1980–1988: MD, Doctoral Cum Laude. Hebrew University, Hadassah Medical School, Jerusalem, Israel.
- 1980–1983: B.Sc., Hebrew University, Hadassah Medical School, Jerusalem, Israel
Experience
- 2025–Present: Member, Research Ethics Board, The Hospital for Sick Children, Toronto, ON
- 2018–Present: Professor, Pediatrics, Immunology, University of Medicine, Toronto, ON
- 2014–Present: Senior Scientist, Developmental and Stem Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, ON
- 2013–Present: Co‑Director and Director, Food Allergy and Anaphylaxis Program, The Hospital for Sick Children, Toronto, ON
- 2013–2024: Chair, Donald and Audrey Campbell Chair for Immunology Research, The Hospital for Sick Children and University of Toronto
- 2012–2025: Chair, Animal Care Committee, The Hospital for Sick Children, Toronto, ON
- 2012–2018: Head, Division of Immunology and Allergy, The Hospital for Sick Children, Toronto, ON
- 2011–2016: Director, Paediatric Clinical Immunology and Allergy Training Program, The Hospital for Sick Children and University of Toronto, Toronto, ON
- 2002–2017: Assistant Professor, Pediatrics, University of Medicine, Toronto, ON
- 2002–2016: Clinician, Blood and Marrow Transplantation Unit, The Hospital for Sick Children, Toronto, ON
- 2002–2014: Scientist (Scientist Track), Developmental and Stem Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, ON
- 2002–Present: Clinician, Division of Immunology and Allergy, The Hospital for Sick Children, Toronto, ON
- 2002–Present: Co‑Director and Director, Advanced Immunology Management (AIM), The Hospital for Sick Children, Toronto, ON
- 1998–2001: Clinical and Research Fellowship in Paediatric Immunology and Allergy, Division of Allergy & Immunology / Blood and Marrow Transplant Unit, The Hospital for Sick Children, Toronto, ON
Publications
- Toro A, Grunebaum E. TAT-mediated intracellular delivery of purine nucleoside phosphorylase corrects its deficiency in mice. J Clin Invest. 2006;116(10):2717-2726. doi:10.1172/JCI25052
- Grunebaum E, Mazzolari E, Porta F, et al. Bone marrow transplantation for severe combined immune deficiency. JAMA. 2006;295(5):508-518. doi:10.1001/jama.295.5.508
- Papinazath T, Min W, Sujiththa S, et al. Effects of purine nucleoside phosphorylase deficiency on thymocyte development. J Allergy Clin Immunol. 2011;128(4):854-863.e1. doi:10.1016/j.jaci.2011.07.039
- Dhanju R, Min W, Ackerley C, et al. Pulmonary alveolar proteinosis in adenosine deaminase-deficient mice. J Allergy Clin Immunol. 2014;133(5):1467-1471.e14714. doi:10.1016/j.jaci.2013.11.029doi:10.1016/j.jaci.2012.02.003
- Kohn DB, Hershfield MS, Puck JM, et al. Consensus approach for the management of severe combined immune deficiency caused by adenosine deaminase deficiency. J Allergy Clin Immunol. 2019;143(3):852-863. doi:10.1016/j.jaci.2018.08.024