Anti-Myeloperoxidase (MPO)

Alternate test name

MPO

Protein

Anti-Myeloperoxidase Antibodies

Lab area

Clinical Biochemistry - Immunology

Method and equipment

Chemiluminescent immunoassay on the BIO-Flash analyzer (Werfen)

Expected turn-around time

10 days

Specimen type

Serum

Specimen requirements

Send: 0.3 mL for 1 test or 0.6 mL min for several of:

aCL
dsDNA
tTG (IgA)
MPO
PR3
anti-SM
SSb
Ro52
Ro60
RNP

Storage and transportation

Frozen

Shipping information

The Hospital for Sick Children

Rapid Response Laboratory

555 University Avenue, Room 3642

Toronto, ON

Canada

M5G 1X8

Phone: 416-813-7200

Toll Free: 1-855-381-3212

Hours: 7 days/week, 24 hours/day

Background and clinical significance

ANCA-associated vasculitis is defined by autoantibodies to proteinase 3 (PR3-ANCA) and myeloperoxidase (MPO-ANCA), which form the main serologic subtypes. PR3-ANCA is typically associated with a cytoplasmic (C-ANCA) pattern and is most often associated with granulomatosis with polyangiitis, while MPO-ANCA shows a perinuclear (P-ANCA) pattern and is more commonly associated with microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis, and renal-limited disease. A positive result is not diagnostic on its own and must be interpreted in the clinical context of the patient.

Disease condition

ANCA-associated vasculitis