Anti-La

Alternate test name

SSB,Anti-La, ENA

Lab area

Clinical Biochemistry - Immunology

Method and equipment

Chemiluminescent immunoassay on the BIO-Flash analyzer (Werfen)

Expected turn-around time

10 working days

Specimen type

Serum

Specimen requirements

Send: 0.3 mL for 1 test or 0.6 mL min for several of:

aCL
dsDNA
tTG (IgA)
MPO
PR3
anti-SM
SSb
Ro52
Ro60
RNP

Storage and transportation

Frozen

Shipping information

The Hospital for Sick Children

Rapid Response Laboratory

555 University Avenue, Room 3642

Toronto, ON

Canada

M5G 1X8

Phone: 416-813-7200

Toll Free: 1-855-381-3212

Hours: 7 days/week, 24 hours/day

Background and clinical significance

Antinuclear antibodies (ANA) are found in a wide variety of connective tissue diseases. ANA positive sera react with several different nuclear antigens, including small nuclear ribonucleoproteins, such as SS-B, also referred to as lupus antigen La. The presence of anti-SS-B autoantibodies, in conjunction with clinical findings and other laboratory tests is an aid in the diagnosis of Sjögren’s Syndrome and Systemic Lupus Erythematosus.