Primidone

Alternate test name

Mysoline

Lab area

Clinical Biochemistry - TDM & Toxicology

Method and equipment

HPLC

Expected turn-around time

Stat: 3 hours Routine: 72 hours

Specimen type

Serum

Plasma (Heparin or Citrate)

Specimen requirements

100 uL

Storage and transportation

Serum/plasma must be separated within 2 hours of collection
Store and ship frozen

Shipping information

The Hospital for Sick Children

Rapid Response Laboratory

555 University Avenue, Room 3642

Toronto, ON

Canada

M5G 1X8

Phone: 416-813-7200

Toll Free: 1-855-381-3212

Hours: 7 days/week, 24 hours/day

Requisition

Primidone - requisition

Background and clinical significance

Primidone is an anticonvulsant drug used primarily in the treatment of complex partial seizures and their secondary generalizations. Primidone is metabolized primarily in the liver. The major metabolite, phenylethylmalonamide has little anticonvulsant activity. The second metabolite, phenobarbital has potent anticonvulsant activity. Due to its long half life, patients on long term primidone therapy should also have the phenobarbital quantitation done along with the primidone. Primidone toxicity may occurr in patients with renal disease. Typical toxic symptoms may include confusion, dizziness, nystagmus and ataxia.

Disease condition

Anticonvulsant