Anti-tissue Transglutaminase IgA

Alternate test name

TTG, EMA, Gliadin, Celiac screening

Lab area

Clinical Biochemistry - Immunology

Method and equipment

Chemiluminescent immunoassay on the BIO-Flash analyzer (Werfen)

Expected turn-around time

10 days

Specimen type

Serum

Specimen requirements

Send: 0.3 mL for 1 test or 0.6 mL min for several of:

aCL
dsDNA
tTG (IgA)
MPO
PR3
anti-SM
SSb
Ro52
Ro60
RNP

Storage and transportation

Frozen

Shipping information

The Hospital for Sick Children

Rapid Response Laboratory

555 University Avenue, Room 3642

Toronto, ON

Canada

M5G 1X8

Phone: 416-813-7200

Toll Free: 1-855-381-3212

Hours: 7 days/week, 24 hours/day

Background and clinical significance

The presence of anti-tissue transglutaminase IgA (anti-tTG IgA) antibodies in serum, in conjunction with clinical findings and other laboratory tests, can aid in the diagnostic evaluation of the gluten sensitive enteropathies celiac disease (CD) and dermatitis herpetiformis (DH).

Disease condition

Celiac disease and dermatitis herpetiformis.