Eytan Wine

Title: Division Head, Gastroenterology, Hepatology and Nutrition.

Designations: MD, PhD, FRCPC

Phone: 416-813-7654 ext. 415142

Email: eytan.wine@sickkids.ca

Fax: 416- 813-4972

External Email: shawana.estwick@sickkids.ca

Alternate Contact Name: Shawana Estwick

Alternate Phone: 416-813-7654 ext.422886

Alternate Email: shawana.estwick@sickkids.ca

Alternate Fax: 416-813-6531

U of T Positions: Professor, Department of Paediatrics Adjunct Professor, Department of Immunology

Chair Positions: Division Head, GHN

Other Positions: Clinician Scientist

Hospital Positions

Staff Physician, Division of Gastroenterology Hepatology and Nutrition.

Co-Lead, SickKids IBD Centre

Research Positions

Senior Scientist, Cell & Systems Biology Program, SickKids Research Institute

Learning Positions

Clinical and lab-based education

Biography

Dr. Eytan Wine completed his medical and paediatric training in Israel, followed by a Paediatric Gastroenterology Fellowship at The Hospital for Sick Children in Toronto. He also earned a PhD in Cellular Microbiology from the University of Toronto. Dr. Wine then moved to the University of AB in Edmonton in 2009, where he developed his clinical and research career as Clinician Scientist, and Paediatric Gastroenterologist, becoming Full Professor of Paediatrics and Physiology in 2021. He returned to SickKids in May 2025.

Dr. Wine is actively involved in national and international collaborations, serving on the Executive of the ESPGHAN Porto IBD Group (2019-2025) and co-chairing the Canadian Children IBD Network (CIDsCaNN). He is co-lead on the ESPGHAN-ECCO Ulcerative Colitis Management Guidelines (JPGN 2025, in press).

Research

Dr. Wine’s clinical expertise lies in the management of children with inflammatory bowel diseases (IBD), including Crohn disease and ulcerative colitis, with a particular focus on dietary therapies such as the Crohn’s Disease Exclusion Diet (CDED). His research, conducted through the Wine Lab at the SickKids Research Institute and the University of Alberta, explores the roles of intestinal bacteria, nutrition, epithelial barrier function, and inflammation in the pathogenesis of IBD. His work bridges basic science and clinical application, enabling impactful translational research.

In addition to his research and clinical work, Dr. Wine is dedicated to education and mentorship, supervising postdoctoral fellows, graduate students, and clinical trainees.

Education and experience

2016–2021: Associate Professor of Paediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
2016–2021: Adjunct Associate Professor of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
2011–2016: Adjunct Assistant Professor of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
2009–2016: Assistant Professor of Paediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
2008–2009: Attending Physician, Transition Faculty, Pediatric Gastroenterology, Division of Gastroenterology, Hepatology, and Nutrition, Hospital for Sick Children, Toronto, ON, Canada
2008–2008: Locum Attending Physician, Paediatric Gastroenterology, Hospital for Sick Children, Toronto, ON, Canada
2006–2007: Chief Fellow, Paediatric Gastroenterology, Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, Hospital for Sick Children, Toronto, ON, Canada.
2003–2004: Attending Physician, Paediatrics, Department of Paediatrics Inpatient Service, Paediatric Gastroenterology Unit, Wolfson Medical Center, Holon, Israel.
2002–2003: Chief Resident, Paediatrics, Department of Paediatrics, Wolfson Medical Center, Holon, Israel.
2001–2004: Part-time Teaching Position, Wolfson Medical Center Nursing School, Holon, Israel.

Achievements

2024: Excellence in Teaching Division Award (Division Member), Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
2021: Annual Teaching Award by Subspecialty Pediatric Residents, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
2020–2021: Excellence in Teaching Division Award (Division Member), Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
2019–2020: Excellence in Teaching Division Award (Division Member), Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
2019: Annual Academic & Clinical Research Paper Author Award (for Armstrong & Wine, Microbiome, 2019), Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
2019: Excellence in Teaching Division Award (Division Member), Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
2018–2019: Preceptor Award in Undergraduate Medical Education, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
2017: Cooperation, Collaboration, and Teamwork Award to the Edmonton Pediatric IBD Clinic (EPIC) (Team Member), Department of Pediatrics, Edmonton, AB, Canada
2015: CIHR Nutrition, Metabolism and Diabetes Partnership New Investigator Prize (Top-ranked application), CIHR, Ottawa, ON, Canada
2015–2018: Best Division Teaching Award (Division Member, all 4 years), Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
2015: Top 10 Teachers of the Year Award (Undergraduate Students Teaching), University of Alberta, Edmonton, AB, Canada
2013: Best Division Teaching Award (Division Member), Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
2012: Young Investigator Travel Award, World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition, Taipei, Taiwan
2011: Future Leaders in IBD (FLIBD) Preceptorship Travel Award, Alimentary Pharmabiotic Centre, Cork University, Cork, Ireland, CCFC Junior Investigator Grant Review Committee Visiting Member
2010: NASPGHAN Single Topic Travel Award, NASPGHAN, New Orleans, Louisiana
2008–2009: Postgraduate Award (Chisholm Memorial Fellowship, Elizabeth Arbuthnot Dyson Fellowship, Miriam Neveren Memorial Award, Edward Christie Stevens Fellowship), Faculty of Medicine, University of Toronto, Toronto, ON, Canada
2008: Best Basic Research Abstract of Excellence Award, CCFA’s Advances in IBD, Hollywood, FL, USA
2007–2008: Postgraduate Award (Javenthey Soobiah, Charles Fell Charitable Trust, Chisholm Memorial Fellowship, Joseph M. West Family Memorial Fund), Faculty of Medicine, University of Toronto, Toronto, ON, Canada
2007: Microbes and Mucosal Immunity Travel Scholarship Award, Society for Mucosal Immunology, Menomonee Falls, Wisconsin
2006–2007: Postgraduate Award (Joseph M. West Family Memorial Fund), Faculty of Medicine, University of Toronto, Toronto, ON, Canada
2005–2006: American Physicians Fellowship for Medicine in Israel Award, Wolfson Medical Center, Israel
2003: Final Oral Exam – Passed with Great Honours, Israeli Medical Board in Pediatrics, Israel
1999: M.D. Thesis of the Year Award and Scholarship – The effect of enzyme replacement therapy in Gaucher's disease, Tel-Aviv University, Tel Aviv, Israel; Supervisor: Ian Cohen

Publications

C. Svolos V, Gordon H, Lomer MCE, Aloi M, Bancil A, Day AS, Day AS, Fitzpatrick JA, Gerasimidis K, Gkikas K, Godny L, Hedin CRH, Katsanos K, Narula N, Russell RK, Sarbagili-Shabat C, Segal JP, Sigall-Boneh R, Sokol H, Wall CL, Whelan K, Wine E, Yanai H, Hansen R, Halmos EP. ECCO Consensus on Dietary Management of Inflammatory Bowel Disease. J Crohns Colitis. 2025 Jul 12:jjaf122. doi: 10.1093/ecco-jcc/jjaf122. Epub ahead of print. PMID: 40650933. Impact Factor 8.70.
C. Baumgart DC, Cheng CH, Du TX, Parkes MD, Sadowski DC, Wine E, Hoentjen F, Halloran BP, Montano-Loza A, Zepeda-Gomez S, Wong K, Peerani F, Goebel R, Ross Mitchell J. Network analysis of extraintestinal manifestations and associated autoimmune disorders in Crohn's disease and ulcerative colitis. NPJ Digit Med. 2025 Apr 15;8(1):209. doi: 10.1038/s41746-025-01504-6. PMID: 40234671; PMCID: PMC12000450. Impact Factor 12.40.
SRA. Sigall Boneh R, Navas-López VM, Hussey S, Pujol-Muncunill G, Lawrence S, Rolandsdotter H, Otley A, Martín-de-Carpi J, Abramas L, Herrador-López M, Egea Castillo N, Chen M, Hurley M, Wingate K, Olen O, Eurenius Rääf T, Yaakov M, Wierdsma N, Van Limbergen J, Wine E. Modified Crohn's Disease Exclusion Diet Maintains Remission in Pediatric Crohn's Disease: Randomized Controlled Trial. Clin Gastroenterol Hepatol. 2024 Dec 26:S1542-3565(24)01131-5. doi: 10.1016/j.cgh.2024.12.006. Epub ahead of print. PMID: 39732356. Impact Factor 12.00.
C. Levine A., Rhodes J. M., Lindsay J. O., Abreu M. T., Kamm M. A., Gibson P. R., Gasche C., Silverberg M. S., Mahadevan U., Boneh R. S., Wine E., Damas O. M., Syme G., Trakman G. L., Yao C. K., Stockhamer S., Hammami M. B Garces, L. C., Rogler, G., … Lewis, J. D. (2020). Dietary Guidance From the International Organization for the Study of Inflammatory Bowel Diseases. Clinical Gastroenterology and Hepatology, 18(6), 1381–1392. https://doi.org/10.1016/j.cgh.2020.01.046. Impact Factor 12.00.
C.Sigall Boneh R, Van Limbergen J, Wine E, Assa A, Shaoul R, Milman P, Cohen S, Kori M, Peleg S, On A, Shamaly H, Abramas L, Levine A. Dietary Therapies Induce Rapid Response and Remission in Pediatric Patients With Active Crohn's Disease. Clin Gastroenterol Hepatol. 2021 Apr;19(4):752-759. doi: 10.1016/j.cgh.2020.04.006. Epub 2020 Apr 14. PMID: 32302709. Impact Factor 12.00.

Funding

2021–2025: Nutri-IBD, Site Lead, Weizmann Institute (PI: Eran Elinav), Israel
2021–2024: Ascertaining Population-Based Long-Term Outcomes in Inflammatory Bowel Disease Patients with Primary Sclerosing Cholangitis, Site Lead, SickKids (PI: Amanda Ricciuto), CCC, $375,000 CAD
2018–2024: DietOmics/Modified-Crohn’s Disease Exclusion Diet (CDED), Co-Principal Investigator (Lead Site Investigator for University of Alberta and Translational DietOmics Project), Tel-Aviv University (PI: Arie Levine)
2018–2024: Post-Operative Crohn's Disease Outcome in Children (POPCORN Trial), Lead Site Investigator for University of Alberta, Tel-Aviv University (PI: Amit Assa)
2014–2027: CIDsCaNN: Canadian Children Inflammatory Bowel Disease Network, Scientific Lead (South-Asian Sub-study; Metabolomics Study), CIHR & CHILD Foundation
2017–2020: Long-Term Outcomes of Pediatric Patients with Acute Severe Colitis, Lead Site Investigator for University of Alberta, Tel-Aviv University (PI: Dror Shouval)
2016–2019: Crohn’s Disease Exclusion Diet (CDED), Site Lead Investigator (Microbial and Metabolomics Sample Analysis), Nestlé (PI: Arie Levine)
2015–2017: PRIMAL: Pediatric Crohn’s Disease – Microbial and Inflammatory Biomarkers of Response to Adalimumab Therapy, Coordinator (Microbial Penetration and Metabolomics; Patient Recruitment), AbbVie (PI: David Mack)
2015–2017: PRASCO: Pediatric Randomized Trial of Antibiotics in Acute Severe Colitis, Site Lead Investigator (Microbial and Metabolomics Sample Analysis), Helmsley Charitable Trust (PI: Dan Turner)
2014–2023: ImageKids: Developing the Pediatric Crohn’s Disease Intestinal Damage (PECDID) Score and Pediatric MRE-Based Activity Index (P-MECAI), Metabolomics and Microbial Interaction Analyst, Abbott (PI: Dan Turner)
2013–2015: AZCRO: Azithromycin-Based Therapy for Induction of Remission in Active Pediatric Crohn’s Disease, National and Site Lead Investigator, Broad Institute (PI: Arie Levine)