Identity Testing - MCC Studies, Zygosity
Maternal Cell Contamination Studies, Zygosity
- cultured amniocytes
- chorionic villus
For details about specimen requirements, please refer to: Specimen Type & Requirements (PDF).
- Blood: 5-10 mL in EDTA, 0.5 mL in EDTA (neonate);
- DNA-minimum 10 ug in 100 uL low TE (pH8.0)
If sending a prenatal sample, please contact the laboratory prior to sending sample to discuss sample requirements.
Blood, DNA: Room Temperature
For details about specimen requirements, please refer to: Specimen Type and Requirements
If sample shipment >48 hours, ship on ice.
Individuals can be distinguished from one another by DNA fingerprinting, which compares nine to sixteen variable DNA markers in different regions of the genome. Each person has their own pattern of markers - a DNA ‘fingerprint’. PCR amplification followed by gel electrophoresis allows comparison of these markers from different individuals. This method can be used to determine the biological relationships between family members such as identity and zygosity testing. Determining the relationships between family members can be very important if a genetic cause for a disease is being considered, since the genetic diagnosis of one family member may apply to the other family members as well. DNA fingerprinting can also be used to evaluate the purity of tissue samples obtained for other kinds of tests. Maternal cell contamination of fetal cell samples obtained for prenatal analysis can be assessed in this way, and sample mix-ups or labeling errors can be detected by using DNA fingerprinting to match tissue samples from the same person taken at different times. DNA fingerprinting is also used to distinguish between the X and Y chromosomes for sex determination.
See related information sheets:
Maternal Cell Contamination (MCC)
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