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Mucopolysaccharides-TLC, urine

Alternate test name

Glycosamine-Glycuronoglycans, urine (GAGS)

Lab area
Clinical Biochemistry - Metabolic Diseases
Method and equipment
Identification of excess dermatan sulfate, heparan sulfate and keratan sulfate in urine by thin layer chromatography (TLC).
Expected turn-around time
30 days
Specimen type

Random Urine

Specimen requirements

15 mL of urine in sterile screw top container.

Storage and transportation
  • Store at 4oC. Keep cool during transport.
Special requirements

MPS TLC is only performed if MPS screen is positive or if Morquio Syndrome suspected (Please specify).

Shipping information
The Hospital for Sick Children
Rapid Response Laboratory
555 University Avenue, Room 3642
Toronto, ON
M5G 1X8
Phone: 416-813-7200
Toll Free: 1-855-381-3212
Hours: 7 days/week, 24 hours/day
Background and clinical significance

Qualitative assessment

Disease condition
  • Hurler Syndrome (MPS Ih)
  • Hurler-Sheie Syndrome (MPS Ih/s)
  • Sheie Syndrome (MPS Is)
  • Hunter Syndrome (MPS II)
  • Sanfilippo Syndrome (MP SIII)
  • Morquio Syndrome (MPS IV)
  • Maroteaux-Lamy Syndrome (MPS VI)
  • Sly Syndrome (MPS VII)
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