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Alpha-1-Acid glycoprotein (AAG), plasma or serum

Alternate test name

Orosomucoid , A1AGP

Lab area
Clinical Biochemistry - General
Method and equipment

Chemiluminescent microparticle immunoassay (CMIA) by Abbott Architect

Expected turn-around time
STAT/ Urgent/ Routine: 24 Hours
Specimen type

Serum or plasma

Specimen requirements

SST Tube preferred, PST Tube is acceptable

Storage and transportation

Specimens may be stored on or off the clot, red blood cells, or separator gel for up to 3 days at room temperature or up to 7 days at 2-8°C. If testing will be delayed more than 7 days, remove serum or plasma from the clot, red blood cells, or separator gel and store at -20°C or colder

Shipping information
The Hospital for Sick Children
Rapid Response Laboratory
555 University Avenue, Room 3642
Toronto, ON
M5G 1X8
Phone: 416-813-7200
Toll Free: 1-855-381-3212
Hours: 7 days/week, 24 hours/day
Background and clinical significance

A1-acid glycoprotein (AGP, orosomucoid) is an acute-phase protein.

Elevated serum levels of A1-acid glycoprotein have been reported in acute and chronic inflammatory conditions, such as myocardial infarction, rheumatoid arthritis, systemic lupus erythematosus, Crohn's disease, chronic renal failure, injuries, burns, and malignancies.

Decreased serum levels of A1-acid glycoprotein can be found in malnutrition, in severe liver damage as well as in women using oral contraceptives (estrogens). 

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