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Bacterial meningitis PCR

Alternate test name

Multiplex PCR bacterial meningitis, partially treated meningitis, Neisseria meningitidisStreptococcus pneumoniaeStreptococcus agalactiae (Group B Streptococcus),  Haemophilus influenzaeListeria monocytogenes,   

Gene name / Alternate gene name


Lab area
Microbiology - Molecular
Method and equipment
Multiplex Polymerase Chain Reaction
Expected turn-around time
8 days
Specimen type
  • CSF
Specimen requirements
  • minimum 300 ul of CSF.  Please ensure adequate sample volume is submitted.
  • send in sterile screw top tube/container.
Storage and transportation
  • All specimens must be shipped on dry ice
  • Exception: Specimens that will arrive at SickKids within 24 hours from the time of collection can be shipped on ice packs
Special requirements

Laboratory Requirements for Testing:

  • CSF pleocytosis (>=50 x 10^6/L WBC)
  • CSF bacterial culture negative at 48 hours

Organisms Tested:

  • Neisseria meningitidis,
  • Streptococcus pneumoniae,
  • Streptococcus agalactiae (Group B Streptococcus), 
  • Haemophilus influenzae,
  • Listeria monocytogenes.  

Please note that this assay does not test for Escherichia coli (E. coli), an important cause of bacterial meningitis in the neonatal population.

Disease condition
  • Culture negative, partially treated bacterial meningitis
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