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Glucose-6-Phosphate Dehydrogenase (G6PD), erythrocytes

Alternate test name


Lab area
Clinical Biochemistry - General
Method and equipment

Dry slide chemistry Vitros 5600

Expected turn-around time
Within 48 working hours of testing date
Specimen type

EDTA whole blood

Storage and transportation

5 day stability (keep refrigerated), send on ice.

Shipping information
The Hospital for Sick Children
Rapid Response Laboratory
555 University Avenue, Room 3642
Toronto, ON
M5G 1X8
Phone: 416-813-7200
Toll Free: 1-855-381-3212
Hours: 7 days/week, 24 hours/day
Background and clinical significance

Glucose-6-phosphate dehydrogenase catalyzes the first step in the pentose phosphate shunt, oxidizing glucose-6-phosphate (G-6-P) to 6-phosphogluconate (6-PG) and reducing NADP to NADPH.

G-6-P + NADP _(G-6-PDH)_> 6-PG + NADPH

The rate of production of NADPH is proportional to G6PD activity. G-6-PDH deficiency is the most common enzymatic deficiency of the red cell. G6PD assay is indicated in the following conditions: drug-induced hemolytic anemia, favism, neonatal icteric and nonspherocytic congenital hemolytic anemia.

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