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Estradiol (High Sensitivity)

Alternate test name

E2, Estrogen

Lab area
Clinical Biochemistry - Special
Method and equipment
Expected turn-around time
15 days
Specimen type

1 mL Serum or Plasma

Specimen requirements
  • Collect 2mL whole blood, spin, separate and freeze (-20oC)
  • Specimens collected on an SST tube should be separated within 90 minutes of receipt.
  • Avoid repeated freeze-thaw cycles.
Storage and transportation


Shipping information
The Hospital for Sick Children
Rapid Response Laboratory
555 University Avenue, Room 3642
Toronto, ON
M5G 1X8
Phone: 416-813-7200
Toll Free: 1-855-381-3212
Hours: 7 days/week, 24 hours/day
Background and clinical significance

Estradiol is the most potent natural estrogen in humans. It regulates  reproductive function in females, and, with progesterone, maintains pregnancy. Most estradiol is secreted by the ovaries (non-pregnant women), although the testes (in men) and adrenal cortex (in men and women) secrete small amounts. During pregnancy, the placenta produces most of the circulating estradiol. Monitoring estradiol levels is essential during in vitro fertilization, because the timing of recovery of oocytes depends on follicular development, which in turn depends on the estradiol level

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