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Carbamazepine, plasma or serum

Alternate test name


Lab area
Clinical Biochemistry - TDM & Toxicology
Method and equipment
Abbott Architect ci4100
Expected turn-around time
STAT/ Urgent/ Routine: 2 hours
Specimen type


Plasma (Heparin or Citrate)

Specimen requirements

150 uL

Storage and transportation

4° C (transport with a cool pack if possible)

Shipping information
The Hospital for Sick Children
Rapid Response Laboratory
555 University Avenue, Room 3642
Toronto, ON
M5G 1X8
Phone: 416-813-7200
Toll Free: 1-855-381-3212
Hours: 7 days/week, 24 hours/day
Background and clinical significance
Carbamazepine is an iminostilbine derivative and is structurally related to the tricyclic antidepressants. Serum (plasma) concentrations between 17 to 50 umol/L have been associated with optimal seizure control in adults. Toxicity associated with carbamazepine therapy is generally minor. The most serious problem is with carbamazepine's ability to suppress bone marrow function. This serious toxic effect, potentially leading to aplastic anemia, is rare. More frequently encountered side effects such as mild drowsiness, vision disturbances, nausea and headache are dose-related and not generally life threatening. Carbamazepine-10,11-epoxide is the major active metabolite of carbamazepine.
Disease condition


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