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SickKids

Vancomycin, plasma or serum

Lab area
Clinical Biochemistry - TDM & Toxicology
Method and equipment
Vitros Fusion 6500
Expected turn-around time
STAT: 60 minutes Urgent/ Routine:120 minutes
Specimen type

Serum, K2EDTA Plasma

Specimen requirements

150 uL

Storage and transportation

4°C (transport with a cool pack if possible)

Shipping information
The Hospital for Sick Children
Rapid Response Laboratory
555 University Avenue, Room 3642
Toronto, ON
Canada
M5G 1X8
Phone: 416-813-7200
Toll Free: 1-855-381-3212
Hours: 7 days/week, 24 hours/day
Background and clinical significance

Vancomycin is a small glycoprotein (MW: 1450) derived from Norcardia Orientalis. Vancomycin is active against many gram positive bacteria and some gram negative cocci. Vancomycin is useful in the treatment of staphylococcal infections in patients who cannot receive or have failed to respond to the penicillins or cephalosporins. Vancomycin kills bacteria by inhibiting bacterial cell wall synthesis. It also damages the bacterial cell membrane and interferes with bacterial RNA synthesis. Vancomycin must be given intravenously as it is poorly absorbed when taken orally and may cause tissue necrosis if injected intramuscularly. Side effects include: flushing of the face, neck and body. Nephrotoxicity and ototoxicity may also occur.

Disease condition

Antibiotic

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