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Salicylate, plasma or serum

Alternate test name

ASA, Aspirin

Lab area
Clinical Biochemistry - TDM & Toxicology
Method and equipment
Abbott Architect ci-4100
Expected turn-around time
Stat/ Urgent/ Routine: 2 hours
Specimen type

Serum, Plasma (Heparin)

Specimen requirements

150 uL

Storage and transportation

4°C (transport with a cool pack if possible)

Shipping information
The Hospital for Sick Children
Rapid Response Laboratory
555 University Avenue, Room 3642
Toronto, ON
M5G 1X8
Phone: 416-813-7200
Toll Free: 1-855-381-3212
Hours: 7 days/week, 24 hours/day
Background and clinical significance

Salicylates, sold as Aspirin or Acetylsalicyclic Acid (ASA), possess anti-inflammatroy, analgesic and antipyretic properties. They are available in many formulations including tablets, capsules, liquids and topical forms such as creams or lotions. Metabolism is primarily hepatic with renal elimination. In overdose situations a severe metabolic acidosis with a compensatory respiratory alkalosis may develop.

Central respiratory centre stimulation a hyperventilation a respiratory alkalosis Inhibition of Krebs Cycle enzymes & uncoupling of oxidative phosphorylation a metabolic acidosis which leads to a increase in glycolysis a hypoglycemia.

Alteration in capillary integrity a pulmonary and cerebral edema.

Alteration of platelet function and prolongation of prothrombin time Clinical symptoms of salicylate toxicity include: pulmonary, auditory (ototoxicity, tinnitus), cardiovascular (tachycardia, hypotension), neurologic (CNS depression, seizures), gastrointestinal (nausea, vomiting), genitourinary (renal failure), hematological and electrolyte disturbances (dehydration, hypokalemia, hypocalcemia & acidemia.

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