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Luteinizing Hormone (LH), serum and plasma

Alternate test name

Gonadotropins include both FSH and LH

Lab area
Clinical Biochemistry - General
Method and equipment
Abbott Ci4100
Expected turn-around time
STAT/ Urgent: 4 hours Routine: 24 hours
Specimen type

Serum, K EDTA plasma

Specimen requirements

150 uL

Storage and transportation


Shipping information
The Hospital for Sick Children
Rapid Response Laboratory
555 University Avenue, Room 3642
Toronto, ON
M5G 1X8
Phone: 416-813-7200
Toll Free: 1-855-381-3212
Hours: 7 days/week, 24 hours/day
Background and clinical significance

LH is a dimeric glycoprotein hormone secreted by the anterior pituitary in response to hypothalamic gonadotrophin releasing hormone. The α-subunit is common to other glycoprotein hormones, while the β-subunit, which confers biological activity, has some homology with that of human chorionic gonadotrophin. During the menstrual cycle, follicle stimulating hormone (FSH) stimulates growth of the ovarian follicle which, when mature, ovulates in response to a surge of LH and, to a lesser extent, of FSH. Ovarian steroids are the primary negative feedback control for LH secretion. At menopause, reduced ovarian negative feedback results in elevated LH concentrations. LH concentrations also tend to be elevated in women of pre‑menopausal age who experience ovarian failure, or whose ovaries failed to mature during puberty.

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