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Scientists receive $2.2 million in research infrastructure support from John R. Evans Leaders Fund
Summary:
The funding will help advance research projects exploring memory function, model organoids and the microbiome’s role in maternal and child health.
Three innovative research projects led by scientists at The Hospital for Sick Children (SickKids) have received research infrastructure funding totaling more than $2.2 million in funding from the Canada Foundation for Innovation (CFI) through its John R. Evans Leaders Fund. The funding will support the development of technologies and platforms to advance research in organoid disease models, memory function, and the microbiome’s role in maternal and child health.
“These remarkable projects exemplify the spirit of innovation and dedication that defines research excellence at SickKids. This CFI investment not only empowers our teams to push the boundaries of science, but it also strengthens our ability to attract top talent and foster discoveries that will improve health outcomes for children and families,” says Dr. Stephen Scherer, Chief of Research.
Funded projects
Next generation platforms for immune-competent organoid models of human disease - $762,062
This project will develop advanced laboratory models known as immune-competent organoids (miniature tissues with integrated immune cells) to help researchers better understand how inflammation and infections contribute to neurodevelopmental disorders and chronic lung conditions like cystic fibrosis. Using cutting-edge equipment, the team will grow and study these organoids in unprecedented detail, enabling new insights in disease progression and potential treatments for patients with complex brain and lung conditions. The project is led by Drs. Yun Li and Amy Wong, Senior Scientists in the Developmental, Stem Cell & Cancer Biology (DSCB) program, and Dr. Julien Muffat, Scientist in the Neurosciences & Mental Health and DSCB program.
Molecular and cellular determinants of memory function and dysfunction - $752,368
This project will investigate how learning alters brain chemistry and the structure of individual cells in preclinical models across their lifespan. Using spatial transcriptomics and advanced monitoring tools, the team will map memory formation and interact with molecules to uncover how the brain learns and remembers in real time. Their findings aim to inform new treatments for memory-related disorders such as dementia, neurodevelopmental conditions and post-traumatic stress disorder. This project is led by Drs. Paul Frankland and Sheena Josselyn, Senior Scientists in the Neurosciences & Mental Health program.
The role of the microbiome in maternal and child health - $693,034
This project will explore how the gut microbiome influences maternal and child health. Using advanced DNA sequencing, imaging and immunological analyses, the team aims to identify which microbes and pathways underlie inflammatory bowel disease, diabetes and malnutrition, with the goal of developing early detection markers and new precision therapies. This project is led by Dr. John Parkinson, Senior Scientist in the Molecular Medicine program, Dr. Jayne Danska, Senior Scientist in the Genetics & Genome Biology program, and Dr. Eytan Wine, Division Head of the Gastroenterology, Hepatology & Nutrition department and Senior Scientist in the Cell & Systems Biology program.