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Ute Bartels

Title:
Academic Clinician, Neuro-Oncology, Division of Haematology/Oncology
Designations:
MD, PhD, M.Sc.
Email:
ute.bartels@sickkids.ca
Alternate Contact Name:
Celine Roussel-Bilokon
Alternate Phone:
416-813-7654 ext. 229907
Alternate Email:
Celine.roussel-bilokon@sickkids.ca
REACH Profile:
Ute Bartel's REACH profile
U of T Positions:
Professor, Department of Paediatrics

Research Positions

Project Investigator
Child Health Evaluative Sciences

Biography

Dr. Ute Bartels is a Staff Neuro-Oncologist at the Hospital for Sick Children (SickKids), Toronto, Project Investigator at Child Health Evaluative Sciences and Professor of Paediatrics at the University of Toronto. She graduated from medical school at Johannes Wolfgang von Goethe University in Frankfurt, Germany and completed her PhD thesis at the Children’s Hospital of the University in Mainz, Germany, where she trained in Paediatrics and specialized in neonatology and paediatric haematology/oncology.

In 2002, she joined SickKids for a fellowship in paediatric neuro-oncology and became a staff physician in 2005. She is an active member of the Central Nervous System (CNS) Committee of the Children’s Oncology Group (COG) in North America, is a Principal Investigator of the CNS Germ Cell Tumour study (ACNS1123) and the Institutional Principal Investigator of COG. She was an invited member of the 2012 International Tuberous Sclerosis Complex (TSC) Consensus Group to finalize diagnostic, surveillance and management recommendations for patients with TSC. She is elected co-chairwoman of the European Society of Paediatric Oncology (SIOPe) Craniopharyngioma Working Group representing the field of oncology/endocrinology since 2011.

Education

  • 1979–1981: Johannes Gutenberg-University Mainz, Germany Education
  • 1982–1986: Medical School, Westfälische Wilhelms-University Münster, Germany
  • 1986–1988: Medical School, Justus Liebig-University, Giessen, Germany
  • 1988–1989: Medical School, Johann Wolfgang v. Goethe-University, Frankfurt, Main. Subject:  Final exam MD
  • Jan 13, 1992: Johannes Gutenberg-University Mainz, Germany. Subject:  Thesis Defence (Dr. med.) PhD equivalence. “The role of the (married) partner in genesis and manifestation of chronic pain syndrome”
  • Nov 6, 1996: Johannes Gutenberg-University Mainz, Germany. Subject:  Specialist for Paediatrics
  • Apr 21, 1997: Johannes Gutenberg-University Mainz, Germany. Subject:  Specialist for Neonatology
  • Aug 1, 1998: Milton H. Erickson Gesellschaft Heidelberg, Germany. Subject:  Specialist for Medical Hypnosis
  • Apr 25, 2007: German Board Exam (newly introduced entitled paediatric subspecialty in Germany in 2007). Subject:  Specialist for Paediatric Haematology and Oncology
  • June 11, 2010: Master of Science, Clinical Epidemiology, University of Toronto

Speciality training

  • 1990–1996: Children's Hospital, Johannes Gutenberg-University, Mainz, Germany. German Board Certification in Paediatrics
  • 1994–1997: Children's Hospital, Johannes Gutenberg-University, Mainz, Germany. German Board Certification in Neonatology
  • 1997–2002: Children's Hospital, Johannes Gutenberg-University, Mainz, Germany. Consultant establishing a Neuro-Oncology Program
  • 2006–2010: Master of Science Program in Clinical Epidemiology at University of Toronto, Toronto, Canada

Experience

  • Sep 1, 2002–Jun 30, 2005: Fellow, Department of Paediatrics, Division of Haematology/Oncology, Paediatric Brain Tumour Program, The Hospital for Sick Children, Toronto, Ontario
  • July 2005–June 2010: Assistant Professor, Department of Paediatrics, University of Toronto, Toronto, Ontario
  • July 2007–Jun 2008: Acting Head of the Paediatric Brain Tumour Program, The Hospital for Sick Children, Toronto, Ontario
  • July 2010–Jun 2016: Associate Professor, Department of Paediatrics, University of Toronto; Toronto, Ontario
  • Aug 2017–Jun 2018: Acting Head of the Paediatric Brain Tumour Program, The Hospital for Sick Children, Toronto, Ontario

Awards

  • 2019: Angela Punnett Mentorship Award
  • 2009: Junior Faculty Award for Clinical Excellence in Paediatric Medical Care
  • 2008: Nomination for Robert Salter Humanitarian Award
  • 2008: Faculty Development Award
  • 2004: ASCO (American Society of Clinical Oncology) Foundation Merit Award

Leadership roles

  • 2020: Data and Safety Monitoring Board Member (DSMB), Stopping TSC Onset and Progression 2: Epilepsy Prevention in TSC Infants (STOP-2)
  • 2018–Present: Institutional Principal Investigator of Children’s Oncology Group (COG)
  • 2017–Present: Ontario CNS Advisory Committee
  • 2016–Present: External Advisory Board Member, CNS Germ Cell Tumor Summary review for NCI Pediatrics cancer treatment summaries.

  • 2017–2020: Principal Investigator. Craniopharyngioma-Interferon Study. Bartels, U. Stiftung Kinderkrebsforschung Mainz (€95,000)
  • 2017–2022: Principal Investigator. Health Related Quality of Life and Symptom Assessment in Patients diagnosed with DIPG and their Caregivers. Schulte F, Bartels, U. Meagan’s Walk ($ 50,000 2017-2022)
  • 2014–2019: Co-Investigator. The Role of Histones in the Development of Pediatric Diffuse Intrinsic Pontine Glioma. Hawkins, C., Bouffet E., Cheung P., Singh S., Bartels, U. Canadian Cancer Society Research Institute ($1,250,000)
  • 2013–2018: Co-Investigator. Predicting deficits in social competence for pediatric brain tumor survivors. M. Barrera, K. Vannatta, A. Patenaude, C. Gerhardt, K Yeates, U. Bartels, Simpkins, & Delaney. NIH/NCI ($566,969)
  • 2012–2014: Co-Investigator. Exercise Intervention in Children Treated with Radiation for Brain Tumors. Mabbott, DJ, Timmons, B., Bartels, U., Bouffet, E., Laughlin, S., Piscione, J., Scantlebury, N., and Scheinemann, K. Canadian Cancer Society Research Institute ($200,000)
  • 2011–2015: Co-Investigator. A randomized control trial to evaluate the efficacy of a social skills intervention for brain tumor childhood survivors. M. Barrera, Sung L, Bartels, U, Janzen, L, Atenafu, A, Cataudella, D, Zelcer, S, Downie, A, Johnston, D, Brandon, S, Schulte, F, Strother, D, Briere, M, Chung, J, Hukin, J, McConnell, D.  Canadian Cancer Society Research Institute ($566,969)
  • 2011–2013: Co-Investigator. Establishment of an International Diffuse Intrinsic Pontine Glioma (DIPG) Registry. Fouladi M, Van Vuurden GD, Warren K, Savage S, Hawkins C, Bouffet E, Bartels U, Hargrave D, Grill J, Jones C, Baker S, Wesseling P, Jacques T, Varlet P, Vezina G, Young Poussaint T, Leach J, Jones B, Saunders D:  Cure Starts Now ($120,000 – 2011-2013)
  • April 2010–March 2011: Co-Investigator. The Neuro-protective effects of exercise in children treated with cranial radiation for brain tumours. Mabbott DJ, Bartels U, Bouffet E, Courneya K, Noseworthy M, Piscione J, Tabori U:  Canadian Institute for Health Research. ($100,000.00)
  • 2009–2013: Principal Investigator. A randomized controlled multicenter non-inferiority trial of twice daily low dose dexamethasone versus high dose dexamethasone for symptom control in children undergoing cranial or craniospinal radiation after complete or near complete resection of a brain tumour. Bartels U: C17 Research Network. ($120,000)
  • 2009–2011: Co-Investigator. Genome wide profiling of pediatric diffuse intrinsic pontine glioma. Hawkins C, Bartels U, Stavropoulos J, Bouffet E:  National Brain Tumor Society (NBTS) Grant Award ($198,670)
  • 2007–2020: Co-Investigator. Weekly vinblastine for chemotherapy naïve children with progressive low-grade glioma. Bouffet E, Pond G, Moghrabi A, Carret AS, Jabado N, Samson Y, Crooks B, Hand JP, Strother D, Wilson B, Hukin J, Mpofu C, Whitton A, Zelcer S, Silva M, Brossard J, Johnston D, Keene D, Bartels U, Tabori U, Hawkins C:  Ontario Institute of Cancer Research ($536, 885)

Publications

  1. Hayden J, Murray MJ, Bartels U, Ajithkumar T, Muthusamy B, Penn A, Calaminus G, Nicholson J. Symptom interval and treatment burden for patients with malignant central nervous system germ cell tumours. Archive of Disease in Childhood. 2020 Mar;105(3):247-252. doi: 10.1136/archdischild-2019-317245. COL.
  2. Weidman D, Palasamudram S, Zak M, Whitney R, McCoy B, Bouffet E, Taylor M, Shrof M, Bartels U. The effect of mTOR inhibition on obstructive hydrocephalus in patients with tuberous sclerosis complex (TSC) related subependymal giant cell astrocytoma (SEGA). Neuro-Oncology. 2020;147:731–736. doi.10.1007/s11060-020-03487-8. SRI
  3. Gottardo NG, Bartels U. "Not all that glitters is gold": insights from the Far East and how to solve a conundrum? Journal of Neuro Oncology. 2019 Dec 17;21(12):1490-1492. doi: 10.1093/neuonc/noz188. SRI.
  4. Fangusaro J, Wu S, MacDonald S, Murphy E, Shaw D, Bartels U, Khatua S, Souweidane M, Lu HM, Morris D, Panigrahy A, Onar-Thomas A, Fouladi M, Gajjar A, Dhall G. Phase II Trial of Response-Based Radiation Therapy for Patients with Localized CNS Nongerminomatous Germ Cell Tumors: A Children’s Oncology Group Study. Journal of Clinical Oncology. 2019 Dec 1;37(34):3283-3290. doi: 10.1200/JCO.19.00701. COL
  5. Egan G., Hamilton J., McKeown T., Bouffet E., Tabori U., Dirks P., Bartels U. Trametinib Toxicities in Patients with Low-grade Gliomas and Diabetes Insipidus: Related Findings? Journal of Pediatric Hematology Oncology. 2019 Jan 22. doi: 10.1097/MPH.0000000000001427. SRI
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