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SickKids

Sonia Grandi

Title: Scientist, Child Health Evaluative Sciences
Designations: M.Sc., PhD
Phone: 416-813-7654 ext. 303619
Email: sonia.grandi@sickkids.ca
Alternate Contact Name: Panagiota Vogdou
Alternate Email: panagiota.vogdou@sickkids.ca
U of T Positions: Assistant Professor, Epidemiology, Dalla Lana School of Public Health

Biography

Sonia Grandi, PhD, is a Scientist at SickKids Research Institute and an Assistant Professor at the University of Toronto in the Division of Epidemiology at the Dalla Lana School of Public Health. She completed her PhD in Epidemiology at McGill University in the Department of Epidemiology, Biostatistics, and Occupational Health. Her dissertation focused on the long-term consequences of pregnancy complications on maternal health.

She completed her postdoctoral fellowship at the Eunice Kennedy Shriver National Institutes of Child Health and Human Development at the National Institutes of Health. Her work focused on the consequences of pregnancy complications on maternal mortality and preconception use of medications on reproductive outcomes in couples attempting to conceive.

Research

Dr. Grandi studies the short- and long-term influence of preconception and perinatal exposures on the health of mothers and children. Her research interests include pregnancy complications, prediction modeling, methods in perinatal and pediatric epidemiology, cardiometabolic health of mothers and infants, and the safety of drugs taken during pregnancy in women with chronic conditions. She has expertise in longitudinal and survival analyses, prediction modeling, and the use of administrative health data.

She has received personal and project funding from the Canadian Institutes of Health Research and the Fonds de recherche du Québec – Santé to examine the safety of levothyroxine in women with subclinical hypothyroidism and the contribution of pregnancy complications to the prediction of cardiovascular disease in women.

Education and experience

  • 2020–2021: Postdoctoral Fellowship, Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institutes of Health Research, Epidemiology Branch, Bethesda, MD, USA
  • 2013–2019: PhD, Epidemiology, Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada
  • 2003–2007: M.Sc., Nutrition, School of Human Nutrition, McGill University, Montreal, QC, Canada
  • 1996–2001: B.Sc., Human Biology, University of Toronto, Toronto, ON, Canada
  • 2005–2012: Research Coordinator, Lady Davis Institute for Medical Research, Centre for Clinical Epidemiology, Jewish General Hospital, McGill University

Achievements

  • 2020–2021: Society for Pediatric and Perinatal Epidemiologic Research, Elected Member of the Executive Committee
  • 2020–2022: Canadian Institutes of Health Research Doctoral Research Awards – B, Peer Review Committee Member
  • 2019: Lady Davis Institute of Medical Research, Paper of the Month, Montreal, QC, Canada
  • 2019: Poster Presentation Prize, First Place: Canadian National Perinatal Research Meeting
  • 2018: Top three most downloaded articles in the last two years, Journal of Pediatric and Perinatal Epidemiology
  • 2017: Oral Presentation Prize, First Place: Department of Epidemiology, Biostatistics, and Occupational Health Research Day, McGill University
  • 2015: Trudy Bush Fellowship for Cardiovascular Disease Research in Women’s Health, American Heart Association

Funding

  • 2017–2022: Co-Investigator. The Risk of Later Cardiovascular Disease in Women with Pregnancy Complications. Canadian Institutes of Health Research - Catalyst Grant – Precision Medicine. Total funding - $200,000. Principal Investigator - Kristian Filion.
  • 2017–2022: Co-Investigator. Levothyroxine for the Treatment of Subclinical Hypothyroidism in Pregnancy: A Population-based Assessment. Canadian Institutes of Health Research - Project Grant. Total Funding: $175,950. Principal Investigator - Kristian Filion.

Publications

  1. Grandi SM, Filion KB, Hutcheon JA, Rosella LA, Platt RW. Accounting for Repeat Pregnancies in Prediction Models. Epidemiology. 2021 Jul 1;32(4):560-568. doi: 10.1097/EDE.0000000000001349.
  2. Grandi SM. Cardiovascular Risk Screening in Women with Pregnancy Complications: The Need for Integrative Strategies. Invited Editorial. Journal of Womens Health (Larchmt). 2020; 30:285-286. doi: 10.1089/jwh.2020.8716.
  3. Grandi SM, Filion KB, Yoon S, Ayele HT, Doyle CM, Hutcheon JA, Gore GC, Smith GN, Ray J, Nerenberg K, Platt RW. Cardiovascular and Cerebrovascular-Related Morbidity and Mortality in Women with a History of Pregnancy Complications: A Systematic Review. Circulation. 2019;139:1069-1079.
  4. Grandi SM, Smith GN, Platt RW. The relative contribution of pregnancy complications to cardiovascular risk prediction: Are we getting it wrong? Circulation. 2019; 140:1965-1967.
  5. Grandi SM, Hinkle SN, Mumford SL, Sjaarda LA, Grantz KL, Mendola P, Mills JL, Pollack AZ, Yeung E, Zhang C, Schisterman EF. Long-term mortality in women with pregnancy loss and modification by race/ethnicity. Under review.
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