Scientist, Child Health Evaluative Sciences
Dr. Hayeems is a Scientist in Child Health Evaluative Sciences (CHES) at SickKids Research Institute and an Associate Professor in the Institute of Health Policy, Management and Evaluation (IHPME) at the University of Toronto. Dr. Hayeems is trained in genetic counselling (ScM, Johns Hopkins University), public health and bioethics (PhD, University of Toronto), health policy research (University of Toronto, IHPME Postdoctoral Fellowship) and health services research (University of Toronto, Institute for Clinical and Evaluative Sciences Postdoctoral Fellowship).
Dr. Hayeems’ research focuses on the development and implementation of high-quality genomic screening and diagnostic tools for the maternal-child health context. Using applied health services and policy research methods, her work focuses on the delivery, evaluation and governance of genomic screening and diagnostic tools in the prenatal, newborn and early childhood periods. As a member of several provincial advisory committees, her work informs and is informed by policy development in this area.
Since joining the Child Health Evaluative Sciences Program at The Hospital for Sick Children Research Institute in January 2014, Dr. Hayeems has established an interdisciplinary, theoretically-grounded, policy-relevant research program focused on (i) outcomes of genomic screening and diagnostic technologies that are important to patients, families, and health-care systems and (ii) novel models of care to support the appropriate, equitable and sustainable delivery of these technologies in child health. Going forward, Dr. Hayeems will broaden the measurement toolkit that she has developed and deepen its integration into novel strategies for delivering care. As precision medicine gains traction, health system funding decisions and policies related to it’s appropriate use will increasingly depend on Dr. Hayeems’ methodologies and research findings.
- 2002–2007: PhD, Dept. Public Health Sciences & Collaborative Program in Bioethics, Faculty of Medicine, University of Toronto, Toronto, ON
- 1998–2001: ScM, Genetic Counselling, John Hopkins Bloomberg School of Public Health, Baltimore, MD and The National Human Genome Research Institute, Bethesda, MD, USA
- 1996–1998: M.Sc., Medical Science, Institute of Medical Science, University of Toronto, Toronto, ON
- 1992–1996: B.Sc. (Hons.), Psychology, McGill University, Montreal, PQ
Postgraduate Research and Specialty Training
- 2011–2013: Postdoctoral Fellowship, Institute for Clinical and Evaluative Sciences, Health System and Policy Evaluation Program, Toronto, ON
- 2008–2010: Postdoctoral Fellowship, Health System Strategy Division, Ontario Ministry of Health and Long-Term Care, Toronto, ON
- 2007–2010: Postdoctoral Fellowship, Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, ON
- 2006–2007: Research Fellow, Centre for Health Economics & Policy Analysis, McMaster University, Hamilton, ON
- 2019–Present: Associate Professor (status), Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON
- 2017–Present: Scientist, Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON
- 2014–2019: Assistant Professor, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON
- 2014–2017: Scientist-track Investigator, Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON
- 2011–2013: Genetic Counsellor, Division of Clinical & Metabolic Genetics, The Hospital for Sick Children, Toronto, ON
- 2001–2005: Genetic Counsellor, Adult Genetics Program, University Health Network, Toronto, ON
- 2022–2027: Canada Research Chair in Genomics and Health Policy, Tier 2, University of Toronto, Toronto, Ontario, Canada.
- 2018: Value Assessment Initiative: Challenge Award (2nd Place) - PhRMA Foundation/ Personalized Medicine Coalition, Washington, DC, USA.
- Co-Chair, Prenatal Screening Ontario - Advisory Committee, Advisory to Prenatal Screening Ontario, Better Outcomes Registry and Network and Ontario Ministry of Health, Ontario, Canada
- Member, Ontario Genetics Advisory Committee, Advisory to Ontario Health (Quality Division), Toronto, Ontario, Canada.
- Hayeems RZ, Bernier FP, Boycott KM, et al. Positioning whole exome sequencing in the diagnostic pathway for rare disease to optimise utility: a protocol for an observational cohort study and an economic evaluation. BMJ Open. 2022; 12(10): E061468.
- Hayeems RZ, Luca S, Venkataramanan V, et al. The Clinician-reported Genetic testing Utility InDEx (C-GUIDE): Preliminary evidence of validity and reliability. Genetics in Medicine. 2022;24(2):430-438.
- Hayeems RZ, Marshall CR, Gillespie MK., et al. Comparing genome sequencing technologies to improve rare disease diagnostics: a protocol for the evaluation of a pilot project, Genome-wide Sequencing Ontario. CMAJ Open. 2022;10(2): E460-E465.
- Hayeems RZ, Luca S, Bhatt A, Abd Assamad D, Ungar W. Utility of Genetic Testing from the Perspective of Parents/Caregivers: A Scoping Review. Children. 2021;8(4):259.
- Hayeems RZ, Dimmock D, Bick D, et al. Clinical utility of genomic testing: A measurement toolkit. NPJ Genomic Medicine. 2020;5(1):56
- 2021–2025: Principal Investigator. The Genetics Navigator: A novel digital platform for delivering personalized genetics. Canadian Institutes of Health Research (CIHR), Team Grant in Personalized Medicine. PIs: Bombard Y, Hayeems RZ. Co-Is: Aronson M, Bernier F, Brudno M, Carroll J, Chad L, Clausen M, Cohn R, Costain G, Dhalla I; Friedman J, Jobling R, Laberge AM, Lerner-Ellis J, Liston E, Mamdani M, Marshall C, Osmond M, Seto E, Shastri-Estrada S, Shuman C, Silver J, Smith M, Thorpe K, Ungar W. Total Amount: $2,000,000 CAD.
- 2022–2024: Co-Investigator. What does this mean for my baby? The impact of exome sequencing on the diagnosis and management of fetal structural anomalies. Academic Health Science Centre (AHSC), AFP Innovation Fund. PI: Armour C. Co-Is: Hayeems RZ, Corsi D, Chitayat D, Walker M. Total Amount: $100,000 CAD.
- 2021–2024: Principal Investigator. Defining and measuring the value of genetic testing from patients' perspectives: Developing the Patient-reported Genetic testing Utility InDEx (P-GUIDE). Canadian Institutes of Health Research (CIHR), Project Grant: Fall 2020. PI: Hayeems RZ. Co-Is: Armstrong L, Birch P, Boycott K, Carroll J, Chad L, Denburg A, Elliott A, Laberge AM, Peltekova I, Smith M, Ungar WJ, Villani A. Collaborators: Cohn RD, Greenberg A, Quinlan B. Total Amount: $508,000 CAD.
- 2021–2024: Co-Investigator. Developing a value framework for the assessment of precision cancer technologies for children. SickKids/Canadian Institutes of Health Research (CIHR), Project Grant: Fall 2020 and Spring 2021. PI: Denburg A. Co-Is: Abelson J, Chan K, Fernandez C, Fraser B, Hayeems RZ, Hodgson D, Malkin D, Palmer A, Peacock S, Regier D, Ungar W. Total Amount: $420,000 CAD.
- 2020–2024: Co-Applicant. An innovative registry-based trials platform to improve clinical care, outcomes, and health policy for children with treatable rare diseases. Canadian Institutes of Health Research (CIHR) Operating Grant: SPOR Innovative Clinical Trial Multi-Year Grant. Principal Applicants: Potter EK, McCabe C, Smith MM, Biknik A, Chakraborty PK, Inbar-Feigenberg M, Mitchell JJ, Offringa M, Oskoui M, Stockler S. Co-Applicants: Adams J, Andrews S, Angel K, Campbell C, Chan A, Clarke L, Coyle D, De Guise M, Dowling J, Dyack S, Geraghty M, Goobie S, Greenberg C, Hayeems RZ, Ho G, Korngut L, Kozenko M, Laberge A, Lacaze-Masmonteil T, Little J, Mackenzie A, Mackenzie J, Mah J, McMillan H, Mhanni A, Pallone N, Pender A, Potter M, Ratko S, Rupar A, Ruth C, Salvarinova R, Schulze A, Selby K, Sondheimer N, Sparkes R, Speechley K, Taljaard M, Thavorn K, Trakadis Y, Turgeon Desilets S, Vandersteen A, Walia J, Wilson B, Wilson K, Boudreault I. Total Amount: $2,755,000 CAD (CIHR), $5,508,000 CAD (Total).
- 2019–2024: Principal Investigator. Beyond the laboratory: Novel strategies for evaluating the utility of pediatric genomics. Ministry of Economic Development, Job Creation and Trade Early Researcher Award Round 15. PI: Hayeems RZ. Total Amount: $150,000 CAD (intended to be used for trainee support).
- 2018–2024: Principal Investigator. Utility and Economic Evaluation Component (Activity 4). Harnessing multi-omics to deliver innovative diagnostic care for rare genetic diseases in Canada (SOLVE-RD Canada). Genome Canada, 2017 Large Scale Applied Research Project. PIs: Boycott K, Brudno M. Co-Lead: Hayeems RZ. Activity 4. Total Amount: $662,728 CAD.
- 2018–2024: Co-Investigator. Harnessing multi-omics to deliver innovative diagnostic care for rare genetic diseases in Canada (SOLVE-RD Canada). Genome Canada, 2017 Large Scale Applied Research Project. PIs: Boycott K, Brudno M. Co-Is: Bowdin S, Bernier S, Dowling J, Hayeems RZ, Knoppers B, Lehman A, Marshall C, Marshall D, Michaud J, McMaster C. Sadikovic B, Simard J, Tauben S, Weksberg R, van Karnebeek C. Total Amount: $11,700,000 CAD.
- 2022–2023: Principal Applicant. Genome-wide Sequencing Ontario: Secondary Findings Impact Study (SF Impact Study). Canadian Institutes of Health Research (CIHR), Strategy for Patient-Oriented Research (SPOR) Priority Announcement. PIs: Hayeems RZ, Ungar W. Co-Is: Beausejour-Ladouceur V, Boycott K, Chad L, Huang L, Jarinova O, Lee W, Mackley M, Marshall C, Mendoza-Londono R, Richer J, Sawyer S, Somerville M, Stavropoulos D, Szuto A, Thibodeau T, Villani A, Zahavich L. Total Amount: $100,000 CAD.
- 2022–2023: Co-Investigator. Building capacity for genome sequencing in under-resourced settings: A global pilot project. McLaughlin Centre for Molecular Medicine, Accelerator Grant in Genomic Medicine 2022. PI: Costain G. Co-Is: Badilla R, Damseh N, Faghfoury H, Hayeems RZ, Liston E, Marshall C, Mendoza-Londono R. Total Amount: $100,000 CAD.
- 2021–2023: Co-Applicant. Enhancing a community of practice for the health system impact fellowship program: Advancing capacity for sustainable & patient-centered learning health systems across Canada. Canadian Institutes of Health Research (CIHR) Health System Impact Fellowship - National Cohort Retreat - National Cohort Training Program Competition. PIs: Marshall D, Bryan S, Doupe M, Gallant N, Lopatina E, Manhas K, McGrail K, Noseworthy T, Singal D, Wasylak T, Zelinsky S. Co-Is: Bielska I, Bruce M, Cheng I, Chishtie J, Cook S, Cressman C, Crowshoe T, Cummings G, Currie G, Hamilton C, Hayeems RZ, Hedden L, Hu J, Ivers N, Lai J, Jewett R, Jose Santana M, Kandola D, King M, Koval A, Kuzmyn T, Lavallee D, Laur C, MacDonald S, Marchand J, Oddone Paolucci E, Parsons Leigh J, Rafferty E, Recsky C, Safari K, Tate K, Van Roosmaln J, Warshafsky D, Weijs C, Zwicker J. Total Amount: $200,000 CAD.
- 2021–2023: Co-Investigator, Evaluation Lead. Optimization and implementation of a clinical genome-wide sequencing service for rare disease diagnosis in Ontario. Genome Canada Genome Applications Partnership Program (GAPP). PIs: Reib B, Boycott K. Co- PI: Somerville M. Co-Is: Ho C, Munter A, Cohn R, Bulman D, Hayeems RZ, Huang L, Jarinova O, Marshall C, McGowan-Jordan J, Mendoza R, Sawyer S, Stavropoulos J, Ungar WJ. $2,000,000 CAD ($4,000,000 CAD co-funding provided by the Ontario Ministry of Health and Long-Term Care). Total Amount: $6,000,000 CAD.
- 2020–2023: Co-Investigator. Access to precision therapies for young people with cancer: Developing a policy framework to guide technology assessment and public funding in Canada. Terry Fox Research Institute (TFRI) New Investigator Grant. PI: Denburg A. Co-Is: Hayeems RZ, Bombard Y, Fernandez C, Knoppers D, Malkin D, Ungar WJ, Villani A, Zawati M. Total Amount: $426,911 CAD.
- 2020–2023: Principal Investigator. i-APPROACH: Integrating a roadmap for prioritizing, evaluating, and implementing precision Child Health. Precision Child Health Catalyst Grant, The Hospital for Sick Children Foundation. PI: Hayeems RZ, Denburg A. Co-Applicants: Barwick M, Birken C, Pechlivanoglou P, Ungar W. Total Amount: $40,000 CAD.
- 2021–2022: Co-Investigator. Rapid genome sequencing for diagnosis and discovery in severe infantile epilepsy. McLaughlin Centre for Molecular Medicine (ON), Accelerator Grant. PI: Constain G. Co-Is: Andrade D, Chau V, Hayeems RZ, Jain P, Marshall CR, Mendoza R, Szuto A, Yuen R. Total Amount: $80,000 CAD.