The Arthur and Sonia Labatt Brain Tumour Research Centre
Dr. Jane McGlade is a Senior Scientist in the Cell Biology Program and Principle Investigator in the Arthur and Sonia Labatt Brain Tumour Research Centre at the Hospital for Sick Children. She is also a Professor of Medical Biophysics at the University of Toronto.
Dr. McGlade received her B.Sc in Biochemistry from the University of Guelph. She completed her PhD with Dr. Philip Branton in the Cancer Research Group at McMaster University and did post-doctoral training with Dr. Tony Pawson at the Lunenfeld Research Institute in Toronto.
The goal of Dr. McGlade’s research program is to understand the specificity and dynamics of protein-protein interactions involved in cell signaling and the molecular basis of signaling events that can be targeted in cancer. Towards this goal, her team focuses on the molecular structure, cellular functions and interaction networks of modular adaptor proteins that regulate critical oncogenic signaling pathways. Currently, the lab is using structural, proteomics, and genetic screening approaches to identify protein networks and specific targets involved in tyrosine kinase signalling and alternative splicing in cancer, as well as high-throughput assays to identify small molecule regulators of ubiquitin ligases.
Education and Experience
- 1979–1983: University of Guelph, B.Sc. (Biochem. and Biomed. Sci.)
- 1984–1990: McMaster University, Ph.D. (Molecular Virology and Immunology)
- 1990–1994: Post-Doctoral Fellow, Samuel Lunenfeld Research Institute, Dr. Tony Pawson Laboratory
- 1994–1999: Assistant Professor, Department of Medical Biophysics, University of Toronto
- 1994–1998: Scientist, Amgen Institute, Toronto
- 1999–2003: Associate Professor, Department of Medical Biophysics, University of Toronto
- 2008–2018: Associate Chief of Research, Faculty Development, The Hospital for Sick Children
- 1999–Present: Principle Investigator, The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children
- 1999–Present: Senior Scientist, Program in Cell Biology, The Hospital for Sick Children Research Institute
- 2003–Present: Professor, Department of Medical Biophysics, University of Toronto
- Zhang, Y., Dho, S. E., Othman, K., Simpson, C. D., Lapierre, J., Bondoc, A., & McGlade, C. J. (2022). Numb exon 9 inclusion regulates Integrinβ5 surface expression and promotes breast cancer metastasis. Oncogene, 41(14), 2079–2094.
- Wybenga-Groot, L. E., Tench, A. J., Simpson, C. D., Germain, J. S., Raught, B., Moran, M. F., & McGlade, C. J. (2021). SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function. Journal of molecular biology, 433(8), 166880.
- Dho, S. E., Silva-Gagliardi, N., Morgese, F., Coyaud, E., Lamoureux, E., Berry, D. M., Raught, B., & McGlade, C. J. (2019). Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins. Scientific reports, 9(1), 12471.
- Lynn, B. D., Li, X., Hormuzdi, S. G., Griffiths, E. K., McGlade, C. J., & Nagy, J. I. (2018). E3 ubiquitin ligases LNX1 and LNX2 localize at neuronal gap junctions formed by connexin36 in rodent brain and molecularly interact with connexin36. The European journal of neuroscience, 48(9), 3062–3081.
- Canadian Institutes of Health Research
- Canadian Cancer Society
- Cancer Research Society
- Natural Sciences and Engineering Research Council of Canada
- Canada Foundation of Innovation
- Meagan's Walk