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SickKids

Brian Nieman

Title: Senior Scientist, Translational Medicine and Mouse Imaging Centre
Designations: PhD
Phone: 416-813-7654 ext. 309555
Email: brian.nieman@sickkids.ca
Fax: 647-837-5832
Alternate Contact Name: Clarisse Cacho
Alternate Phone: 416-813-7654 ext. 309536
Alternate Email: Clarisse.cacho@sickkids.ca
REACH Profile: Brian Nieman's REACH profile
U of T Positions: Associate Professor, Department of Medical Biophysics

Biography

Dr. Brian Nieman is currently a Senior Scientist at the Mouse Imaging Centre (MICe) at SickKids Research Institute and a Level 2 Investigator with the Ontario Institute for Cancer Research. He is appointed to the Department of Medical Biophysics at the University of Toronto. His current research focuses on development of imaging methods for evaluating mouse models of disease and for evaluating the impact of pediatric cancer treatment on development in cancer survivors, with particular focus on the brain.

Dr. Nieman received his PhD in 2006 from the Department of Medical Biophysics at the University of Toronto. His thesis described the development of magnetic resonance imaging (MRI) methods for the analysis of mouse models of human disease. From 2006 to 2009, Brian was a post-doctoral fellow with Dr. Daniel H. Turnbull at the New York University School of Medicine. He has been a member of the Research Institute since 2009.

Research

The Nieman lab focuses on characterization of disease or development processes both spatially and temporally in relevant mouse models.

Education

  • 2006–2009: Postdoctoral Fellowship, New York University School of Medicine, New York, NY, USA
  • 2001–2006: PhD, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
  • 1997–2001: B.Sc., Department of Physics, University of Waterloo, Waterloo, ON, Canada

Experience

  • 2019–Present: Associate Professor, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
  • 2015–Present: OICR Investigator, Level 2, Ontario Institute for Cancer Research, Toronto, ON, Canada
  • 2010–2019: Assistant Professor, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
  • 2015–Present: Senior Scientist, Mouse Imaging Centre, Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada
  • 2009–2015: Scientist, Mouse Imaging Centre, Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, ON, Canada
  • 2009–2015: OICR New Investigator, Ontario Institute for Cancer Research, Toronto, ON, Canada

Publications

  1. K.G. Beera, Y.Q. Li, J. Dazai, J. Stewart, S. Egan, M. Ahmed, C.S. Wong, D.A. Jaffray, B.J. Nieman. Altered brain morphology after focal radiation reveals impact of off-target effects: implications for white matter development and neurogenesis. Neuro-Oncology 20(6):788-798, 2018.
  2. T. L. Spencer Noakes, T.S. Przybycien, A. Forwell, C. Nicholls, Y.-Q. Zhou, D.T. Butcher, R. Weksburg, S.L. Guger, B.J. Spiegler, R.J Schachar, J. Hitzler, S. Ito, E. van der Plas, B.J. Nieman. Brain development and heart function after systemic single-agent chemotherapy in a mouse model of childhood leukemia treatment. Clinical Cancer Research, 24(23):6040-6052, 2018.
  3. B.J. Nieman, M.C. van Eede, S. Spring, J. Dazai, R.M. Henkelman, J.P. Lerch. MRI to assess neurological function. Current Protocols in Mouse Biology 8(2):44, 2018.
  4. E. van der Plas, T.L. Spencer Noakes, D.T. Butcher, R. Weksberg, L. Galin-Corini, E.A. Wanstall, P. Te, L. Hopf, S. Guger, B.J. Spiegler, J. Hitzler, R.J. Schachar, S. Ito, B.J. Nieman. Quantitative MRI outcomes in child and adolescent leukemia survivors: evidence for global alterations in gray and white matter. NeuroImage: Clinical, 2020. 28:102428.
  5. E. van der Plas, T.L. Spencer Noakes, D.T. Butcher, R. Weksberg, L. Galin-Corini, E.A. Wanstall, P. Te, L. Hopf, S. Guger, B.J. Spiegler, J. Hitzler, R.J. Schachar, S. Ito, B.J. Nieman. Quality of life in child and adolescent leukemia survivors. Pediatric Research, 2020.

See a full list of Brian Nieman's publications

  • 2020–2025: How does chemotherapy to treat childhood cancer affect brain development? B.J. Nieman, Canadian Institutes of Health Research, $933,300 CAD
  • 2020–2025: How does parental diet program brain structure? M. Palmert, B.J. Nieman, Canadian Institutes of Health Research, $843,730 CAD
  • 2020–2025: Advanced imaging of mouse development: early adversity and brain health. J.G. Sled, B.J. Nieman, John R. Evans Leaders Fund, $798,440 CAD
  • 2018–2023: Limiting late effects following pediatric cranial radiation. B.J. Nieman, Canadian Institutes of Health Research, $994,500 CAD
  • 2017–2022: MRI of the mouse: linking structure, function, and disease. J.G. Sled, Canada Foundation for Innovation – Innovation Grant 2017, $4,135,120 CAD
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