Michael D. Taylor
Developmental and Stem Cell Biology
Born and raised in Canada, Dr. Taylor attended The University of Western Ontario and earned his medical degree in 1994. His education and training continued at the University of Toronto, where he earned his PhD in Molecular Genetics in 2002, and his residency training in Neurosurgery in 2003. Dr. Taylor then won a Detweiler Traveling Fellowship from the Royal College of Physicians and Surgeons of Canada for fellowship training in paediatric neurosurgery and paediatric neuro-oncology at St. Jude Children’s Research Hospital in Memphis, where he completed a post-doctoral fellowship in Cancer Genomics in the Department of Developmental Neurobiology.
Dr. Taylor joined the Division of Neurosurgery at The Hospital for Sick Children (SickKids) in 2004, and is a Professor of Surgery at the University of Toronto, and a Senior Scientist in the Developmental and Stem Cell Biology Program at the SickKids Research Institute. He is also the Garron Family Chair for Childhood Cancer Research at SickKids. He has published over 330 peer-reviewed publications, many in high-impact journals such as Nature, Science, Cell, Cancer Cell, Nature Genetics, and Lancet Oncology.
The Taylor Lab’s research centres on the molecular genetics of medulloblastoma and ependymoma, two of the most common malignant paediatric brain tumours.
Education and experience
- 1994: Medicine (cum laude) MD, University of Western Ontario, London, Ontario
- 2003: FRCS Neurosurgery, University of Toronto, Ontario
- 2002: PhD, Molecular Genetics of Paediatric Brain Tumours, University of Toronto, Ontario
- 2003–2004: Post-Doc, Cancer Genomics, St. Jude Children’s Research Hospital, Memphis, Tennessee
- 2004–2005: Post Doc, Functional Genomics, University of Toronto, Ontario
- 2004–Present: Staff Neurosurgeon, The Hospital for Sick Children
- 2004–2010: Assistant Professor, Department of Surgery, University of Toronto
- 2004–2012: Scientist, Program in Developmental Biology, The Hospital for Sick Children
- 2010–2013: Associate Professor, Department of Surgery, University of Toronto
- 2012–Present: Senior Scientist, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children
- 2013–Present: Professor, Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto
- 2008: Canada’s Top 40 under 40 award
- 2009: Canadian Cancer Society Award. Young Investigator Award in Biomedical Science
- 2010: Royal College of Physicians and Surgeons of Canada Gold Medal Award in Surgery
- 2010: Canadian Institute of Health Research, Clinician-Scientist Award, Phase II - Renewal
- 2011: George-Armstrong Peters Prize in Surgery, University of Toronto
- 2013: Garron Family Endowed Chair in Childhood Cancer Research, Hospital for Sick Children
- 2015: Canadian Cancer Society William E. Rawls Prize for 2015
- 2016: Lister Prize in Surgery. University of Toronto 2016
- 2016: Voynick Award in Neuro-Oncology 2016. Yale University
- 2016: Guha Award in Neuro-Oncology 2016. Society for Neuro-Oncology
- 2016: Zulch Prize in Basic Neuroscience 2016. Max Planck Society
- 2019: H. Richard Winn, MD Prize. The Society of Neurological Surgeons
- 2019: The Distinguished Oliver Smithies Lecture. McLaughlin Centre of the University of Toronto
- 2019: Fellow and Member of the Royal Society of Canada
- Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma. Cell. 2020 Jun 11;181(6):1329-1345.e24. doi: 10.1016/j.cell.2020.04.047. Epub 2020 May 22. PMID: 32445698
- Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma. Nat Med. 2020 Apr 27. doi: 10.1038/s41591-020-0827-2. [Epub ahead of print]. PMID: 32341580
- Recurrent non-coding U1-snRNA mutations drive cryptic splicing in Shh medulloblastoma. Nature. 2019 Oct 9. doi: 10.1038/s41586-019-1650-0. [Epub ahead of print] PMID: 31597162.
- The U1 spliceosomal RNA is recurrently mutated in multiple cancers. Nature. 2019 Oct;574(7780):712-716. doi: 10.1038/s41586-019-1651-z. Epub 2019 Oct 9. PMID: 31597163.
- Childhood cerebellar tumours mirror conserved fetal transcriptional programs. Nature. 2019 Aug;572(7767):67-73. doi: 10.1038/s41586-019-1158-7. Epub 2019 May 1. PMID: 31043743.
- SickKids Foundation
- Garron Family Foundation
- Rally Foundation
- Swifty Foundation
- Meagan’s Walk
- Canadian Cancer Society Research Institute
- Genome Canada
- Genome BC
- Genome Quebec
- Stand Up to Cancer (US and Canada)
- Ontario Research Fund
- Cancer Research UK