SickKids research awarded over $14 million through CIHR Fall 2024 Project Grant funding

Posted on February 10, 2025

Summary:

Fifteen grants were awarded for projects ranging from studying cancer phenotypes to outcomes for neonatal infants who undergo major surgery.

The Hospital for Sick Children (SickKids) researchers received a total of $14,184,144 in funding as part of the CIHR Project Grant Fall 2024 competition. The 15 grants awarded to SickKids’ Principal Investigators cover a diverse range of subjects and are led by scientists from various research programs at the SickKids Research Institute. The competition approved 453 research grants across Canada for a total investment of approximately $411 million.

Nominated Principal Investigator	Research Institute Program	Project Title	Total Funding Amount
Ronald Cohn	Genetics & Genome Biology	Next-generation gene editing for DMD: efficacy and safety of AAV-compatible adenine base and prime editing in a humanized mouse model	$990,675
Glenda Courtney-Martin	Translational Medicine	To complement or not complement- Is protein complementation at each meal necessary when consuming plant-based diets?	$1,422,900
Ashish Deshwar	Developmental, Stem Cell & Cancer Biology	Elucidating the role of ZPR1 in lipid metabolism and fatty liver pathogenesis	$1,143,675
Linda Hiraki	Genetics & Genome Biology	Understanding the immunophenotype and genetics of treatment response in children and adolescents with lupus nephritis	$501,076
Andrea Kassner	Translational Medicine	Development of multi-spectral hyperpolarized xenon MRI approaches for measuring cerebral hemodynamics and oxygenation in pediatric cerebrovascular disease	$750,745
Michael Moran	Cell & Systems Biology	Metabolism-driven cancer phenotypes and therapeutic vulnerabilities	$963,900
Indra Narang	Translational Medicine	Continuous positive airway pressure vs high flow nasal cannula for the treatment of OSA in children (CHOSA Trial)	$952,425
Deborah O'Connor	Translational Medicine	High pressure processing of donor human milk to improve fat absorption in preterm infants (The HiPP Study)	$898,875
Mercedes Pilkington	Child Health Evaluative Sciences	Implementing enhanced recovery after surgery (ERAS) for neonates undergoing major surgery: A prospective multicentre stepped-wedge cluster hybrid effectiveness-implementation study	$646,423
Amanda Ricciuto	Child Health Evaluative Sciences	Unravelling the cellular and immunologic landscape of the gut in children with primary sclerosing cholangitis at single-cell resolution	$822,376
Natasha Saunders	Child Health Evaluative Sciences	Pediatric outcomes of children whose mothers experience violence: A multi-province study	$569,924
Ian Scott	Developmental, Stem Cell & Cancer Biology	Function of an antagonistic Gata5/Tbx1 regulatory loop in establishing the epigenetic framework for cardiopharyngeal development and disease	$1,086,300
Michael Wilson	Genetics & Genome Biology	Liver sinusoidal endothelial cell inflammatory gene regulatory networks in health and disease	$1,143,675
Ryan Yuen	Genetics & Genome Biology	Identifying genetic and epigenetic modifiers for schizophrenia in a high-risk population	$1,147,500
Augusto Zani	Developmental, Stem Cell & Cancer Biology	Stem cell extracellular vesicles as a regenerative therapy for hypoplastic lungs: Translational studies in lamb fetuses with congenital diaphragmatic hernia	$1,143,675